| + |
CARM1 | up-regulates activity 
methylation
|
SMARCC1 |
0.552 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251708 |
Arg1064 |
PGNILGPrVPLTAPN |
Homo sapiens |
HEK-293 Cell, Breast Cancer Cell Line |
| pmid |
sentence |
| 24434208 |
CARM1-mediated BAF155 methylation affects gene expression by directing methylated BAF155 to unique chromatin regions (e.g., c-Myc pathway genes). Collectively, our studies uncover a mechanism by which BAF155 acquires tumorigenic functions via arginine methylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CARM1 | down-regulates activity 
methylation
|
RUNX1 |
0.285 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261967 |
Arg223 |
PAPTPNPrASLNHST |
Homo sapiens |
Hematopoietic Stem Cell |
| pmid |
sentence |
| 24332853 |
We have found that PRMT4 is highly expressed in HSPCs, where it functions as an inhibitor of myeloid differentiation (Figure 7G). In these cells, PRMT4 methylates RUNX1 at R223, promoting the assembly of a DPF2-containing transcriptional co-repressive complex, and repressing transcription at the miR-223 locus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CARM1 | down-regulates activity
acetylation
|
MDH1 |
0.362 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267639 |
Arg230 |
FVTTVQQrGAAVIKA |
Homo sapiens |
|
| pmid |
sentence |
| 27840030 |
Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer|Arginine methylation at R248 negatively regulates MDH1 activity|PRMT4/CARM1 methylates MDH1 at R248 and inhibits its dimerization |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK12 | down-regulates activity
phosphorylation
|
CARM1 |
0.347 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255897 |
Ser595 |
GPAISMAsPMSIPTN |
Mus musculus |
|
| pmid |
sentence |
| 29681515 |
Here, we identify a role for the mitogen-activated protein kinase (MAPK) p38g/MAPK12 as a critical regulator of satellite stem cell fate through phosphorylation of Carm1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CARM1 | down-regulates 
|
Differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261968 |
|
|
Homo sapiens |
Hematopoietic Stem Cell |
| pmid |
sentence |
| 24332853 |
PRMT4 blocks myeloid differentiation of human hematopoietic stem/progenitor cells While PRMT4 promotes differentiation in several biological systems including T cell, adipocyte and muscle development, it blocks differentiation in the hematopoietic system, allowing HSPCs to maintain stemness. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CARM1 | up-regulates
methylation
|
PAX7 |
0.43 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255898 |
|
|
Mus musculus |
Satellite Cell |
| pmid |
sentence |
| 29681515 |
Carm1 specifically methylates Pax7 at multiple arginine residues in the N terminus of Pax7 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198617 |
|
|
Homo sapiens |
Satellite Cell |
| pmid |
sentence |
| 22863532 |
Carm1 specifically methylates multiple arginines in the n-terminus of pax7. Methylated pax7 directly binds the c-terminal cleavage forms of the trithorax proteins mll1/2 resulting in the recruitment of the ash2l:mll1/2:wdr5:rbbp5 histone h3k4 methyltransferase complex to regulatory enhancers and the proximal promoter of myf5. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| Tissue: |
Skeletal Muscle, Muscle, Skeletal Muscle |
| + |
CARM1 | up-regulates
methylation
|
MEF2A |
0.396 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255964 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 29163212 |
The first evidence alluding to a role of PRMTs in mediating skeletal muscle plasticity, specifically myogenesis, arose from the identification of CARM1 as a glucocorticoid receptor-interacting protein 1 (GRIP1) binding protein. (Chen et al., 2000). Here, GRIP1 and MEF2 were co-expressed in the nucleus during skeletal muscle differentiation. These initial findings led to an investigation that revealed that this methyltransferase was responsible for coactivating the transcription of myocyte enhancer factor-2C (MEF2C) via GRIP1 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Skeletal Muscle |
| + |
KRAS | down-regulates activity
|
CARM1 |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267640 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 27840030 |
Interestingly, overexpression of KRASG12V (an activating mutant) in BxPC-3 cells, a PDAC cell line carrying wild-type KRAS, led to a 40% decrease of CARM1 protein and consequent hypomethylation or activation of MDH1|These observations indicate that KRAS suppresses CARM1-mediated MDH1 methylation, contributing to Gln metabolism in pancreatic cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-mir-223 | down-regulates quantity by repression
post transcriptional regulation
|
CARM1 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261970 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24332853 |
PRMT4 is downregulated by miR-223 during normal myeloid differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CARM1 | form complex 
binding
|
MAPK12/CARM1 |
0.347 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255980 |
|
|
|
|
| pmid |
sentence |
| 29681515 |
Basal localization of the p38γ/p-Carm1 complex in muscle stem cells occurs via binding to the dystrophin-glycoprotein complex (DGC) through β1-syntrophin. In dystrophin-deficient muscle stem cells undergoing asymmetric division, p38γ/β1-syntrophin interactions are abrogated |
|
| Publications: |
1 |
| Tissue: |
Skeletal Muscle |
3.0
CARM1
- 
- 