Name CARM1
Full Name Histone-arginine methyltransferase CARM1
Synonyms Coactivator-associated arginine methyltransferase 1, Protein arginine N-methyltransferase 4 | PRMT4
Primary ID Q86X55
Links - -
Type protein
Relations 6
Function Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.


Modifications Tables


Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png methylation SMARCC1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CARM1 0.08
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ form complex img/form-complex.png binding MAPK12/CARM1 0.08
Publications: 1
Tissue: Skeletal Muscle
+ up-regulates img/direct-activation.png methylation MEF2A 0.08
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ up-regulates img/direct-activation.png methylation PAX7 0.14
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Tissue: Muscle, Skeletal Muscle, Skeletal Muscle