| + |
ERBB2 | down-regulates quantity by destabilization 
phosphorylation
|
BBC3 |
0.281 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276472 |
Tyr152 |
ADDLNAQyERRRQEE |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 24236056 |
HER2 phosphorylates and destabilizes pro-apoptotic PUMA. Using an intracellular assay, we found PUMA to be phosphorylated in breast cancer cells with activated HER2. Via cell-free HER2 kinase assay, we observed that PUMA was directly phosphorylated by HER2. Activation of HER2 decreased PUMA protein half-life. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276474 |
Tyr172 |
PSPWRVLyNLIMGLL |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 24236056 |
HER2 phosphorylates and destabilizes pro-apoptotic PUMA. Using an intracellular assay, we found PUMA to be phosphorylated in breast cancer cells with activated HER2. Via cell-free HER2 kinase assay, we observed that PUMA was directly phosphorylated by HER2. Activation of HER2 decreased PUMA protein half-life. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276473 |
Tyr58 |
PTLLPAAyLCAPTAP |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 24236056 |
HER2 phosphorylates and destabilizes pro-apoptotic PUMA. Using an intracellular assay, we found PUMA to be phosphorylated in breast cancer cells with activated HER2. Via cell-free HER2 kinase assay, we observed that PUMA was directly phosphorylated by HER2. Activation of HER2 decreased PUMA protein half-life. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
BBC3 | down-regulates
binding
|
BCL2L2 |
0.552 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133814 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15694340 |
Only bimbh3 and bbc3 had comparable strong affinitiesfor all the prosurvival proteins. The members that promote cell survival, including mammalian bcl-2, bcl-xl,bcl-w, mcl-1, and a1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BBC3 | down-regulates activity
binding
|
BCL2L1 |
0.761 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133811 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15694340 |
Only bimbh3 and bbc3 had comparable strong affinities for all the prosurvival proteins. The members that promote cell survival, including mammalian bcl-2, bcl-xl,bcl-w, mcl-1, and a1.Puma promotes bax translocation by both by directly interacting with bax and by competitive binding to bcl-x(l) in uv-induced apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Mitochondrial Control of Apoptosis |
| + |
BBC3 | down-regulates activity
binding
|
BCL2 |
0.664 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133808 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15694340 |
Only bimbh3 and bbc3 had comparable strong affinitiesfor all the prosurvival proteins. The members that promote cell survival, including mammalian bcl-2, bcl-xl,bcl-w, mcl-1, and a1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-109506 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 11463392 |
Puma localizes to the mitochondria, interacts with bcl-2, and function to induce cytochrome c release |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Death Receptor Signaling, Mitochondrial Control of Apoptosis |
| + |
BBC3 | up-regulates 
binding
|
BAK1 |
0.382 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152974 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17289999 |
Bh3-only proteins induce apoptosis at least primarily by engaging the multiple pro-survival relatives guarding bax and bak enabler bh3-only proteins such as puma promote momp more indirectly. They activate bax and bak by forming inhibitory complexes with the anti-apoptotic bh1-4 proteins such as bcl2, bclxl and mcl1 that normally stabilize the outer membrane. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196929 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22492984 |
Bim, and puma bind with high affinity to all pro-survival proteins |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
TP53 | up-regulates quantity by expression 
transcriptional regulation
|
BBC3 |
0.696 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-140245 |
|
|
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 16151013 |
Nuclear p53 caused expression of puma, which then displaced p53 from bcl-xl, allowing p53 to induce mitochondrial permeabilization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Mitochondrial Control of Apoptosis |
| + |
BBC3 | up-regulates
binding, relocalization
|
BAX |
0.49 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-20064 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1557433 |
The first Helix of bax plays a necessary role in its ligand-induced activation by the bh3-only proteins bid and puma |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-185671 |
|
|
Homo sapiens |
Lung Cancer Cell |
| pmid |
sentence |
| 19439449 |
Puma promotes bax translocation by both by directly interacting with bax and by competitive binding to bcl-x(l) in uv-induced apoptosis. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Death Receptor Signaling, Mitochondrial Control of Apoptosis |
| + |
KDM4B | down-regulates quantity by repression 
transcriptional regulation
|
BBC3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263732 |
|
|
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 28073943 |
JMJD2B induction attenuates the transcription of key p53 transcriptional targets including p21, PIG3 and PUMA, and this modulation is dependent on the catalytic capacity of JMJD2B. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BBC3 | down-regulates
binding
|
MCL1 |
0.753 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-133817 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15694340 |
Only bimbh3 and bbc3 had comparable strong affinities for all the prosurvival proteins. The members that promote cell survival, including mammalian bcl-2, bcl-xl,bcl-w, mcl-1, and a1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR4A3 | up-regulates quantity by expression
transcriptional regulation
|
BBC3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259396 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30455429 |
Over-expression of NR4A3 attenuated proliferation of cancer cells and promoted apoptosis by augmenting the expression of pro-apoptotic genes, PUMA and Bax. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ER stress | up-regulates
|
BBC3 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196938 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22492984 |
Exposure to stress results in the induction of bh3-only proteins, which neutralise the pro-survival proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Mitochondrial Control of Apoptosis |
4.0
BBC3
- 
- 