| + |
SIRT5 | down-regulates activity 
post translational modification
|
SHMT2 |
0.237 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267644 |
Lys280 |
IVTTTTHkTLRGARS |
|
|
| pmid |
sentence |
| 34929314 |
Mitochondrial serine hydroxymethyl transferase (SHMT2) is a rate-limiting enzyme that catalyzes the catabolism of serine and drives the proliferation of osteosarcoma cells and colon cancer cells. SIRT5 directly mediates the desuccinylation of Lysine 280 on SHMT2. Therefore, SIRT5 is a candidate target to inhibit serine catabolism |
|
| Publications: |
1 |
| + |
SIRT5 | up-regulates activity 
post translational modification
|
HMGCS2 |
0.355 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267642 |
Lys310 |
PFCKMVQkSLARLMF |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24315375 |
We demonstrate that SIRT5 regu-lates succinylation of the rate-limiting ketogenicenzyme 3-hydroxy-3-methylglutaryl-CoA synthase 2(HMGCS2) both in vivo and in vitro.|Succinylation of Lysine Residues within the SubstrateBinding Pocket Inhibits HMGCS2 Activity|Here, we use a label-freequantitative proteomic approach to characterizethe lysine succinylome in liver mitochondria and itsregulation by the desuccinylase SIRT5 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267641 |
Lys83 |
YNNVEAGkYTVGLGQ |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24315375 |
We demonstrate that SIRT5 regu-lates succinylation of the rate-limiting ketogenicenzyme 3-hydroxy-3-methylglutaryl-CoA synthase 2(HMGCS2) both in vivo and in vitro.|Succinylation of Lysine Residues within the SubstrateBinding Pocket Inhibits HMGCS2 Activity|Here, we use a label-freequantitative proteomic approach to characterizethe lysine succinylome in liver mitochondria and itsregulation by the desuccinylase SIRT5 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SIRT5 | up-regulates activity
deacetylation
|
LDHB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267645 |
Lys329 |
DTLWDIQkDLKDL |
Homo sapiens |
Colorectal Cancer Cell |
| pmid |
sentence |
| 34929314 |
In colorectal cancer, SIRT5 binds to lactate dehydrogenase B (LDHB) to deacetylate it at Lysine 329, thereby increasing its enzymatic activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT5 | down-regulates activity
catalytic activity
|
ACOX1 |
0.265 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261210 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 29491006 |
SIRT5‐mediated desuccinylation inhibits ACOX1 activity by suppressing its active dimer formation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT5 | up-regulates activity
post translational modification
|
CPS1 |
0.528 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267643 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 24703693 |
Glutarylation suppresses CPS1 activity, which is targeted by SIRT5 for removal|SIRT5 can catalyze the enzymatic removal of lysine glutarylation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT5 | up-regulates quantity by expression 
transcriptional regulation
|
NFE2L2 |
0.315 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261208 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31815138 |
Western blot showed that Sirt5 overexpression upregulated Nrf2. Sirt5 attenuates apoptosis through Nrf2/HO-1 and Bcl-2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT5 | up-regulates activity
catalytic activity
|
G6PD |
0.284 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261211 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27113762 |
Here, we report that SIRT5 desuccinylates and deglutarylates isocitrate dehydrogenase 2 (IDH2) and glucose-6-phosphate dehydrogenase (G6PD), respectively, and thus activates both NADPH-producing enzymes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT5 | up-regulates activity
catalytic activity
|
IDH2 |
0.424 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261212 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27113762 |
Here, we report that SIRT5 desuccinylates and deglutarylates isocitrate dehydrogenase 2 (IDH2) and glucose-6-phosphate dehydrogenase (G6PD), respectively, and thus activates both NADPH-producing enzymes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT5 | up-regulates quantity by expression
transcriptional regulation
|
BECN1 |
0.325 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261206 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31608237 |
In SIRT5 silenced Mero-14 cells, beclin-1 protein levels were downregulated upon rotenone and resveratrol treatment. In summary, in most cases, where significant effects were detected, SIRT1, SIRT3, and SIRT5 had positive effects on beclin1 and LC3II/LC3I ratio |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT5 | up-regulates quantity by expression
transcriptional regulation
|
SIRT3 |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261209 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31608237 |
In U2OS cells, SIRT5 silencing resulted in downregulation of SIRT1 and SIRT3 protein levels (Figures 4Ai,ii, compare bars 1 to 5). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BAG3 | down-regulates quantity by repression 
transcriptional regulation
|
SIRT5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261205 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30910998 |
Ectopic BAG3 expression decreases the interaction between GLS and SIRT5. we demonstrated that BAG3 overexpression decreased SIRT5 expression in HepG2 cells (Fig. 5d). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT5 | up-regulates activity
binding
|
GLS |
0.463 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261207 |
|
|
Homo sapiens |
HepG2-N10 Cell |
| pmid |
sentence |
| 30910998 |
Immunoprecipitation assays of interaction between GLS and SIRT5 in HepG2 cells infected with lentivirus containing empty or BAG3 construct. Ectopic BAG3 expression decreases the interaction between GLS and SIRT5. It has been reported that SIRT5 is responsible for desuccinylation of GLS35, immunoprecipitation (IP) was then performed. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SIRT5
- 
- 