Summary

Name TAOK2
Full Name Serine/threonine-protein kinase TAO2
Synonyms Kinase from chicken homolog C, hKFC-C, Prostate-derived sterile 20-like kinase 1, PSK-1, PSK1, Prostate-derived STE20-like kinase 1, Thousand and one amino acid protein kinase 2 | KIAA0881, MAP3K17, PSK, PSK1
Primary ID Q9UL54
Links - -
Type protein
Relations 12
Pathways P38 Signaling
Function Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ TAOK2up-regulates activity img/direct-activation.png phosphorylation, binding MAP2K6 0.633
Publications: 2 Organism: Homo Sapiens
Pathways:P38 Signaling
+ TAOK2up-regulates activity img/direct-activation.png phosphorylation, binding MAP2K3 0.654
Publications: 2 Organism: Homo Sapiens, In Vitro
Pathways:P38 Signaling
+ TAOK2up-regulates activity img/direct-activation.png phosphorylation ELK1 0.314
Publications: 1 Organism: Homo Sapiens
+ DNA_damageup-regulates img/indirect-activation.png TAOK2 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ TAOK2up-regulates img/direct-activation.png phosphorylation STK3 0.278
Publications: 1 Organism: Homo Sapiens
+ TAOK2up-regulates activity img/direct-activation.png binding MAP2K4 0.262
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ TAOK2up-regulates img/direct-activation.png binding MAP2K7 0.2
Publications: 1 Organism: Homo Sapiens
+ TAOK2up-regulates img/direct-activation.png phosphorylation STK3/4 0.283
Publications: 1 Organism: Homo Sapiens
+ GNAO1up-regulates img/indirect-activation.png TAOK2 0.2
Publications: 1 Organism: Homo Sapiens
+ TAOK2up-regulates img/direct-activation.png phosphorylation STK4 0.283
Publications: 1 Organism: Homo Sapiens