| + |
gamma-secretase | up-regulates activity 
cleavage
|
NOTCH3 |
0.558 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209726 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25610395 |
The membrane-bound Notch segment that results from this cleavage, known as Notch Intracellular Truncation domain (NEXT), is a -secretase substrate (Kopan and Ilagan, 2009). -Secretase performs the subsequent cleavage at S3 (De Strooper et al., 1999), releasing Notch intracellular domain (NICD) from the membrane and allowing for signal transduction through binding with the CBL-1, Su(H), Lag-1 (CSL; Schroeter et al., 1998; Struhl and Adachi, 1998) family of DNA binding proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DLL1 | up-regulates
binding
|
NOTCH3 |
0.614 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-82398 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11006133 |
These results suggest that delta1, jagged1, and jagged2 are ligands for notch1 and notch3 receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAML1 | up-regulates
binding
|
NOTCH3 |
0.781 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-84838 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11101851 |
Maml1 binds to the ankyrin repeat domain of all four mammalian notch receptors, forms a dna-binding complex with icn and rbp-jkappa, and amplifies notch-induced transcription of hes1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAML3 | up-regulates
binding
|
NOTCH3 |
0.877 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-94100 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12370315 |
We report here the cloning and characterization of two new genes, maml2 and maml3, that also function as transcriptional coactivators for notch receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH3 | up-regulates
binding
|
RBPJ |
0.852 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-86128 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11404076 |
Both notch 1 and notch 3 ics displace the co-repressor smrt from the dna-binding protein rbp-j kappa on the hes promoter. The latter observation suggests that both notch 3 ic and notch 1 ic can access rbp-j kappa in vivo, and that the difference in activation capacity instead stems from structural differences in the two ics when positioned on rbp-j kappa. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO | down-regulates quantity 
transcriptional regulation
|
NOTCH3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252941 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24749067 |
We demonstrate that FOXO3, perhaps by activating Notch signaling, promotes the quiescent state during SC self-renewal in adult muscle regeneration. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
JAG1 | up-regulates
binding
|
NOTCH3 |
0.628 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179625 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18660822 |
Here we report the first x-ray structure of a functional fragment of a notch ligand, the dsl-egf3 domains of human jagged-1 (j-1dsl-egf3). The structure identifies a highly conserved face of the dsl domain and we show, by functional analysis of drosophila ligand mutants, that this surface is required for both cis- and trans-regulatory interactions with notch. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO3 | down-regulates quantity
transcriptional regulation
|
NOTCH3 |
0.312 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244079 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24749067 |
We demonstrate that FOXO3, perhaps by activating Notch signaling, promotes the quiescent state during SC self-renewal in adult muscle regeneration. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NOTCH3 | up-regulates quantity by expression 
transcriptional regulation
|
HEYL |
0.593 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83402 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11044625 |
In the latter, heyl is coexpressed with notch3, so far the only notch pathway gene detected in vascular smooth muscles (fig. 2h,i;joutel et al., 2000). Both genes are also coexpressed during late thymus development and our own promoter studies further suggest a potential regulation of heyl transcription by notch3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Smooth Muscle |
| + |
NOTCH3 | up-regulates quantity by expression
transcriptional regulation
|
HES1 |
0.596 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174750 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 21743488 |
We demonstrate that her2 overexpression in this cellular model of dcis drives transcriptional upregulation of multiple components of the notch survival pathway. Importantly, luminal filling required upregulation of a signaling pathway comprising notch3, its cleaved intracellular domain and the transcriptional regulator hes1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAG2 | up-regulates
binding
|
NOTCH3 |
0.608 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-82401 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11006133 |
These results suggest that delta1, jagged1, and jagged2 are ligands for notch1 and notch3 receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERBB2 | up-regulates quantity by expression
transcriptional regulation
|
NOTCH3 |
0.413 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174747 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 21743488 |
We demonstrate that her2 overexpression in this cellular model of dcis drives transcriptional upregulation of multiple components of the notch survival pathway. Importantly, luminal filling required upregulation of a signaling pathway comprising notch3, its cleaved intracellular domain and the transcriptional regulator hes1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TCF12 | up-regulates quantity by expression
transcriptional regulation
|
NOTCH3 |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197517 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 22577461 |
Hebalt positively regulates t-cell genes, such as pt_ and notch3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NOTCH3
- 
- 