Summary

Name FZD1
Full Name Frizzled-1
Synonyms Fz-1, hFz1, FzE1
Primary ID Q9UP38
Links - -
Type protein
Relations 14
Pathways FAP: Wnt
Function Receptor for Wnt proteins (PubMed:10557084). Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (PubMed:10557084). Contradictory results showing activation by WNT7B have been described for mouse (By similarity). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:10557084). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:10557084). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding FZD1 0.789
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DVL3 0.642
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png PPARG 0.283
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding FZD1 0.689
Publications: 3 Organism: Mus Musculus, Homo Sapiens
Tissue: Muscle, Muscle, Skeletal Muscle
+ up-regulates activity img/direct-activation.png binding DVL2 0.665
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DVL1 0.676
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding FZD1 0.65
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FZD1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FZD1 0.656
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Lung, Smooth Muscle
+ up-regulates img/direct-activation.png binding FZD1 0.65
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png CEBPA 0.2
Publications: 1 Organism: Homo Sapiens