| + |
WNT10B | up-regulates 
binding
|
FZD2 |
0.626 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-89137 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12055200 |
Inhibition of adipogenesis by wnt10b is likely mediated by wnt receptors, frizzled 1, 2, and/or 5, and co-receptors low density lipoprotein receptor-related proteins 5 and 7 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT10B | up-regulates 
|
CTNNB1 |
0.488 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176190 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21872687 |
We show that knockdown of Beta-catenin completely prevents the inhibition of adipogenesis and stimulation of osteoblast differentiation by wnt6, wnt10a or wnt10b |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT10B | up-regulates
binding
|
LRP5 |
0.58 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-131628 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15578921 |
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SOSTDC1 | down-regulates activity 
|
WNT10B |
0.391 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242698 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22829579 |
Our laboratory identified an almost twofold upregulation of sclerostin domain-containing 1 (Sostdc1; also referred to as WISE, USAG-1, ectodin), a dual Bmp/Wnt inhibitor, in postnatal day (P)1 pancreata from transgenic mice misexpressing hepatocyte nuclear factor (Hnf)6 in islet endocrine cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
WNT10B | up-regulates
binding
|
FZD5 |
0.604 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210164 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12055200 |
Inhibition of adipogenesis by wnt10b is likely mediated by‚ wnt‚ receptors, frizzled 1, 2, and/or 5, and co-receptors low density lipoprotein receptor-related proteins 5 and 8 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT10B | up-regulates activity
binding
|
FZD1 |
0.651 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253511 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19008118 |
In mesenchymal precursor cells, Wnt10b (and Wnt10a) binding to frizzled (FZD1) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT10B | up-regulates activity
binding
|
LRP6 |
0.606 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-131631 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15578921 |
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT10B | down-regulates
|
Adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-89131 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12055200 |
We have identified wnt10b as a potent inhibitor of adipogenesis that must be suppressed for preadipocytes to differentiate in vitro |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT10B | up-regulates
binding
|
FZD3 |
0.601 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-131625 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15578921 |
Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WNT10B | up-regulates
binding
|
FZD1 |
0.651 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-89134 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12055200 |
Inhibition of adipogenesis by wnt10b is likely mediated by wnt receptors, frizzled 1, 2, and/or 5, and co-receptors low density lipoprotein receptor-related proteins 5 and 6 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
WNT10B
- 
- 