4.0
Summary
| Name |  GIT1View Modifications |
| Full Name | ARF GTPase-activating protein GIT1 |
| Synonyms | ARF GAP GIT1, Cool-associated and tyrosine-phosphorylated protein 1, CAT-1, CAT1, G protein-coupled receptor kinase-interactor 1, GRK-interacting protein 1 |
| Primary ID | Q9Y2X7 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Pathways | Macropinocytosis |
| Function | GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve ENTR1 and PTPN13 (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKD3 |
phosphorylation
|
GIT1 | 0.362 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SRC | up-regulates activity 
phosphorylation
|
GIT1 | 0.542 |
| Publications: | 2 | Organism: | Chlorocebus Aethiops | |
| + | GIT1 | up-regulates activity
guanine nucleotide exchange factor
|
ARF6 | 0.716 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAT2B | up-regulates activity
binding
|
GIT1 | 0.399 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GIT1 | up-regulates
binding
|
PLCG1 | 0.558 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Muscle, Smooth Muscle | |||
| + | RAC1 | up-regulates activity
binding
|
GIT1 | 0.657 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GIT1 | up-regulates activity
binding
|
ARHGEF6 | 0.848 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GIT1 | up-regulates activity
binding
|
MAP2K1 | 0.392 |
| Publications: | 1 | Organism: | Homo Sapiens | |