Summary

Name DAAM1
Full Name Disheveled-associated activator of morphogenesis 1
Synonyms DAAM1_HUMAN | KIAA0666
Primary ID Q9Y4D1
Links - -
Type protein
Relations 4
Pathways Satellite: WNT, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
Function Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/indirect-activation.png RAC1 0.42
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding DAAM1 0.724
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding DAAM1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RHOA 0.815
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis