4.0
Summary
| Name |  MAP3K4View Modifications |
| Full Name | Mitogen-activated protein kinase kinase kinase 4 |
| Synonyms | MAP three kinase 1, MAPK/ERK kinase kinase 4, MEK kinase 4, MEKK 4 | KIAA0213, MAPKKK4, MEKK4, MTK1 |
| Primary ID | Q9Y6R4 |
| Links |  -  -  |
| Type | protein |
| Relations | 10 |
| Pathways | P38 Signaling |
| Function | Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAP3K4 | up-regulates activity 
phosphorylation
|
MAP3K4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | P38 Signaling | |||
| + | MAP3K4 | up-regulates activity
phosphorylation
|
MAP2K3 | 0.647 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | P38 Signaling | |||
| + | MAP3K4 | up-regulates activity
phosphorylation
|
MAP2K6 | 0.667 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Pathways: | P38 Signaling | |||
| + | MAP3K4 | up-regulates activity 
|
MAPK14 | 0.379 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | P38 Signaling | |||
| + | MAP3K7 | up-regulates activity
|
MAP3K4 | 0.291 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | P38 Signaling | |||
| + | GSK3B | down-regulates 
binding
|
MAP3K4 | 0.358 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | UV stress | up-regulates
|
MAP3K4 | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | P38 Signaling | |||
| + | MAP3K4 | up-regulates activity
phosphorylation
|
MAP2K4 | 0.585 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | P38 Signaling | |||
| + | AXIN1 | up-regulates
binding
|
MAP3K4 | 0.41 |
| Publications: | 1 | Organism: | Homo Sapiens | |