| + |
Wnt | up-regulates activity 
binding
|
LPR5/6 |
0.802 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256174 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23209147 |
FZD and LRP5/6 transduce Wnt signal via engaging downstream cytoplasmic components, among which two scaffolding proteins, Dishevelled and Axin, have prominent roles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hepatocellular Tumor, Wnt in cancer |
| + |
LRP6 | form complex 
binding
|
LPR5/6 |
0.375 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256175 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27821587 |
Low-density lipoprotein receptor-related proteins 5 and 6 (LRP5/6) are co-receptors for Wnt ligands. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LPR5/6 | down-regulates activity 
binding
|
GSK3B/Axin/APC |
0.698 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256177 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19107203 |
These observations demonstrate that phosphorylated lrp6/5 both recruits and directly inhibits gsk3beta using two distinct portions of its cytoplasmic sequence. binding of wnts to the coreceptors frizzled and lrp6/5 leads to phosphorylation of pppspxs motifs in the lrp6/5 intracellular region and the inhibition of gsk3beta bound to the scaffold protein axin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hepatocellular Tumor, Wnt in cancer |
| + |
LRP5 | form complex
binding
|
LPR5/6 |
0.375 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256176 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27821587 |
Low-density lipoprotein receptor-related proteins 5 and 6 (LRP5/6) are co-receptors for Wnt ligands. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
LPR5/6