| + |
Caspase 8 complex | down-regulates activity 
cleavage
|
RIPK1 |
0.906 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256442 |
Asp324 |
RMQSLQLdCVAVPSS |
Homo sapiens |
HEK-293 Cell, MCF-7 Cell, HeLa Cell |
| pmid |
sentence |
| 10521396 |
These results suggested that the aspartic acid at position 324 is the cleavage site of ripk1. In this study we found that receptor-interacting protein (ripk1) is cleaved by casp8 when cells undergo tnf-induced apoptosis. The cleavage of ripk1 abolished its nf-kb inducing ability. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 8 complex | up-regulates activity 
cleavage
|
BID |
0.872 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256443 |
Asp60 |
GYDELQTdGNRSSHS |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 9727492 |
Caspase-8 cleaves bid at aspartic acid residue 60 (asp60) cleavage of bid by casp8 releases its potent proapoptotic activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 8 complex | up-regulates activity
cleavage
|
CASP3 |
0.707 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256451 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 10988287 |
The temporal pattern of caspase-8 cleavage is consistent with the possibility that it may function upstream of caspase-3 during p53-dependent apoptosis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256458 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16964285 |
Casp8 induces apoptosis by directly activating casp3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256452 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21295084 |
Triggering of the DISC leads to caspase-8 activation. Active caspase-8 cleaves caspase-3 which, in type I cells, leads to cell death induction. |
|
| Publications: |
3 |
Organism: |
Mus Musculus, Homo Sapiens |
| + |
Caspase 8 complex | up-regulates 
|
Apoptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256549 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14585074 |
Downstream of caspase-8 activation, apoptosis induction takes place |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 8 complex | up-regulates
cleavage
|
CASP7 |
0.723 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256459 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9727491 |
Casp8 can activate downstream caspases like caspase-6, and caspase-7 by directly cleaving them. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256454 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18073771 |
Active caspase-8 then proteolytically processes and activates caspase-7 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
Caspase 8 complex | up-regulates activity
|
CYCS |
0.502 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256473 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 10364179 |
Caspase-8 triggered rapid cytochrome c release from mitochondria. The effect was indirect. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Caspase 8 complex | up-regulates activity
|
CASP9 |
0.59 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256479 |
|
|
in vitro |
|
| pmid |
sentence |
| 10988287 |
One indirect means through which caspase-8 might regulate caspase-9 activation is through a bcl-2-regulated pathway. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
Caspase 8 complex | up-regulates
cleavage
|
CASP6 |
0.716 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256466 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9727491 |
Casp8 can activate downstream caspases like caspase-6, and caspase-7 by directly cleaving them. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CASP8 | form complex 
binding
|
Caspase 8 complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256395 |
|
|
|
|
| pmid |
sentence |
| 10508785 |
Activated caspase-8 (an alpha2beta2 heterotetramer) activates other downstream caspases that are incapable of autocatalytic processing and activation. |The alphabeta dimeric protein associates further to form an alpha2beta2 heterotetramer that appears to be required for catalytic activity. |
|
| Publications: |
1 |
| + |
Caspase 8 complex | up-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256641 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14585074 |
Downstream of caspase-8 activation, apoptosis induction takes place |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Caspase 8 complex
CPX-975