Relation Results

Summary

Name	PTTG1 View Modifications
Full Name	Securin
Synonyms	Esp1-associated protein, Pituitary tumor-transforming gene 1 protein, Tumor-transforming protein 1, hPTTG \| EAP1, PTTG, TUTR1
Primary ID	O95997
Links	- -
Type	protein
Relations	22
Function	Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.

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▶Modifications Tables

Relations

Regulator

Mechanism

target

score ℹ

up-regulates img/direct-activation.png

img/direct-activation.png

phosphorylation

0.309

Publications:

1

Organism:

Homo Sapiens

up-regulates img/direct-activation.png

img/direct-activation.png

phosphorylation

0.359

Publications:

1

Organism:

Homo Sapiens

up-regulates img/direct-activation.png

img/direct-activation.png

phosphorylation

0.617

Publications:

1

Organism:

Homo Sapiens

down-regulates quantity by destabilization img/direct_inhibition.png

img/direct_inhibition.png

phosphorylation

0.2

Publications:

2

Organism:

Homo Sapiens

down-regulates quantity by destabilization img/direct_inhibition.png

img/direct_inhibition.png

phosphorylation

0.314

Publications:

4

Organism:

Homo Sapiens

up-regulates quantity by stabilization img/direct-activation.png

img/direct-activation.png

dephosphorylation

0.301

Publications:

4

Organism:

Homo Sapiens

down-regulates activity img/direct_inhibition.png

img/direct_inhibition.png

binding

0.943

Publications:

1

Organism:

Homo Sapiens

up-regulates img/direct-activation.png

img/direct-activation.png

phosphorylation

0.2

Publications:

1

Organism:

Homo Sapiens

up-regulates quantity by expression img/indirect-activation.png

img/indirect-activation.png

transcriptional regulation

0.275

Publications:

1

Organism:

Homo Sapiens

up-regulates img/direct-activation.png

img/direct-activation.png

phosphorylation

0.2

Publications:

1

Organism:

Homo Sapiens

up-regulates quantity by expression img/indirect-activation.png

img/indirect-activation.png

transcriptional regulation

0.2

Publications:

1

Organism:

Homo Sapiens

up-regulates activity img/indirect-activation.png

img/indirect-activation.png

0.7

Publications:

1

Organism:

Mus Musculus

down-regulates quantity by destabilization img/direct_inhibition.png

img/direct_inhibition.png

ubiquitination

0.553

Publications:

1

down-regulates quantity img/indirect_inhibition.png

img/indirect_inhibition.png

0.2

Publications:

1

Organism:

Homo Sapiens

down-regulates quantity by destabilization img/direct_inhibition.png

img/direct_inhibition.png

polyubiquitination

0.2

Publications:

1

Organism:

Homo Sapiens