Summary

Name ERBB2
Full Name Receptor tyrosine-protein kinase erbB-2
Synonyms Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2 | HER2, MLN19, NEU, NGL
Primary ID P04626
Links - -
Type protein
Relations 60
Pathways Colorectal Carcinoma
Inhibitors Neratinib; Lapatinib Ditosylate; AZD8931; Afatinib; Canertinib dihydrochloride; CP-724714; CUDC-101; VARLITINIB; AV412; Dacomitinib; XL-647; Arry-380; 873837-23-1; AEE 788; Mubritinib
Function Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation ERBB2 0.06
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ERBB2
Publications: 4 Organism: In Vitro
Pathways:Colorectal Carcinoma
+ down-regulates img/direct_inhibition.png phosphorylation ERBB2
Publications: 2 Organism: Homo Sapiens
Tissue: Breast
Pathways:Colorectal Carcinoma
+ up-regulates img/direct-activation.png phosphorylation ERBB2
Publications: 4 Organism: Homo Sapiens
Tissue: Breast
Pathways:Colorectal Carcinoma
+ down-regulates activity img/direct_inhibition.png dephosphorylation ERBB2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ERBB2 0.90
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DOCK7 0.06
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDK1 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ERBB3 0.81
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MSI1 0.03
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates img/direct-activation.png binding ERBB4 0.51
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary, Lung
+ up-regulates img/direct-activation.png binding ERBB2 0.41
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ERBB2 0.07
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOTCH3 0.03
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination ERBB2 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination ERBB2 0.05
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization SHC3 0.02
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SHC1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ERBB2 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ESR1
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization GRB2 0.17
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ERBB2 0.02
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ERBB2 0.09
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ERBB2 0.90
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PLCG1 0.13
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown ERBB2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown ERBB2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ERBB2 0.05
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EGFR 0.90
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2
Publications: 1 Organism: Homo Sapiens