| + |
PRKACA | up-regulates 
phosphorylation
|
ERBB2 |
0.06 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-181191 |
Thr686 |
QQKIRKYtMRRLLQE |
Homo sapiens |
|
| pmid |
sentence |
| 18799465 |
Pka directly phosphorylated erbb2 on thr-686, a highly conserved intracellular regulatory site that was required for the pka-mediated synergistic enhancement of neuregulin-induced erbb2-erbb3 activation and proliferation in scs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERBB2 | down-regulates 
phosphorylation
|
ERBB2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-21207 |
Tyr1023 |
DLVDAEEyLVPQQGF |
Homo sapiens |
|
| pmid |
sentence |
| 1706616 |
However, each of these peptides contains tyrosines that correspond to major autophosphorylation sites of the epidermal growth factor receptor, suggesting that, in addition to y1023 and y1248, y1139 and y1222 also serve as autophosphorylation sites of her2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-21211 |
Tyr1112 |
DPSPLQRySEDPTVP |
Homo sapiens |
|
| pmid |
sentence |
| 1706616 |
However, each of these peptides contains tyrosines that correspond to major autophosphorylation sites of the epidermal growth factor receptor, suggesting that, in addition to y1023 and y1248, y1139 and y1222 also serve as autophosphorylation sites of her2. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Breast |
| Pathways: | Colorectal Carcinoma |
| + |
ERBB2 | up-regulates activity
phosphorylation
|
ERBB2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251129 |
Tyr1023 |
DLVDAEEyLVPQQGF |
in vitro |
|
| pmid |
sentence |
| 1706616 |
Y1023 and Y1248, Y1139 and Y1222 also serve as autophosphorylation sites of HER2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251127 |
Tyr1139 |
TCSPQPEyVNQPDVR |
in vitro |
|
| pmid |
sentence |
| 1706616 |
Y1023 and Y1248, Y1139 and Y1222 also serve as autophosphorylation sites of HER2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251130 |
Tyr1222 |
PAFDNLYyWDQDPPE |
in vitro |
|
| pmid |
sentence |
| 1706616 |
Y1023 and Y1248, Y1139 and Y1222 also serve as autophosphorylation sites of HER2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251128 |
Tyr1248 |
PTAENPEyLGLDVPV |
in vitro |
|
| pmid |
sentence |
| 1706616 |
Y1023 and Y1248, Y1139 and Y1222 also serve as autophosphorylation sites of HER2. |
|
| Publications: |
4 |
Organism: |
In Vitro |
| Pathways: | Colorectal Carcinoma |
| + |
ERBB2 | up-regulates
phosphorylation
|
ERBB2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124856 |
Tyr1196 |
GAVENPEyLTPQGGA |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 15156151 |
Stimulation of these molecules, however, failed to induce efficient cell migration in the absence of neu/erbb2 phosphorylation at tyr 1201 or tyr 1227 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-21199 |
Tyr1221 |
SPAFDNLyYWDQDPP |
Homo sapiens |
|
| pmid |
sentence |
| 1706616 |
However, each of these peptides contains tyrosines that correspond to major autophosphorylation sites of the epidermal growth factor receptor, suggesting that, in addition to y1023 and y1248, y1139 and y1222 also serve as autophosphorylation sites of her2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124860 |
Tyr1222 |
PAFDNLYyWDQDPPE |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 15156151 |
Stimulation of these molecules, however, failed to induce efficient cell migration in the absence of neu/erbb2 phosphorylation at tyr 1201 or tyr 1227 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-21203 |
Tyr1248 |
PTAENPEyLGLDVPV |
Homo sapiens |
|
| pmid |
sentence |
| 1706616 |
However, each of these peptides contains tyrosines that correspond to major autophosphorylation sites of the epidermal growth factor receptor, suggesting that, in addition to y1023 and y1248, y1139 and y1222 also serve as autophosphorylation sites of her2. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Tissue: |
Breast |
| Pathways: | Colorectal Carcinoma |
| + |
DUSP3 | down-regulates activity
dephosphorylation
|
ERBB2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248534 |
Tyr1221 |
SPAFDNLyYWDQDPP |
Homo sapiens |
NCI-H1299 Cell |
| pmid |
sentence |
| 21262974 |
Expression of VHR inhibited the activation of phospholipase Cγ and protein kinase C, both downstream effectors of Tyr-992 phosphorylation of EGFR. | We found that VHR decreased ErbB2 phosphorylation in vitro and in a cellular context, and the dephosphorylation of ErbB2 was more evident at Tyr-877 and Tyr-1221 than those at Tyr-1139 and Tyr-1248 (supplemental Fig. S1). Our data indicated that VHR was a cellular PTP against EGFR and ErbB2. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248533 |
Tyr877 |
LDIDETEyHADGGKV |
Homo sapiens |
NCI-H1299 Cell |
| pmid |
sentence |
| 21262974 |
Expression of VHR inhibited the activation of phospholipase Cγ and protein kinase C, both downstream effectors of Tyr-992 phosphorylation of EGFR. | We found that VHR decreased ErbB2 phosphorylation in vitro and in a cellular context, and the dephosphorylation of ErbB2 was more evident at Tyr-877 and Tyr-1221 than those at Tyr-1139 and Tyr-1248 (supplemental Fig. S1). Our data indicated that VHR was a cellular PTP against EGFR and ErbB2. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PTPRG | up-regulates activity
dephosphorylation
|
ERBB2 |
0.05 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254701 |
Tyr1248 |
PTAENPEyLGLDVPV |
in vitro |
|
| pmid |
sentence |
| 25624455 |
PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and VCL correlates with tyrosine dephosphorylation. In contrast, SRC inhibition correlates with hyperphosphorylation of the inhibitory Tyr530 residue and with dephosphorylation of the activatory Tyr419. Moreover, CDK2 and CTTN inhibition correlates with a hyperphosphorylation of the inhibitory Tyr15 and Tyr470, respectively. In contrast, a subgroup of 13 proteins, including BLNK, DOK2, ERBB2, GRIN2B, INSR, PDGFRA, PRKCD, PXN, STAT1, STAT2, STAT3, STAT5A, and ZAP70, appears to be activated by PTPRG activity. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
EGFR | up-regulates activity
phosphorylation
|
ERBB2 |
0.90 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251094 |
Tyr1248 |
PTAENPEyLGLDVPV |
Homo sapiens |
Breast Cancer Cell Line |
| pmid |
sentence |
| 12354693 |
Induction of cancer cell migration by epidermal growth factor is initiated by specific phosphorylation of tyrosine 1248 of c-erbB-2 receptor via EGFR. | In summary, c-erbB-2 up-regulation switches on the cell migration program by modulating the time course of PLC-gamma1 activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERBB2 | up-regulates
phosphorylation
|
DOCK7 |
0.06 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178348 |
Tyr1257 |
METVPQLyDFTETHN |
Homo sapiens |
|
| pmid |
sentence |
| 18426980 |
We show that the nrg1 receptor erbb2 directly binds and activates dock7 by phosphorylating tyr-1118. thus, dock7 functions as an intracellular substrate for erbb2 to promote schwann cell migration. This provides an unanticipated mechanism through which ligand-dependent tyrosine phosphorylation can trigger the activation of rho gtpase-gefs of the dock180 family. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERBB2 | down-regulates
phosphorylation
|
CDK1 |
0.08 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-88671 |
Tyr15 |
EKIGEGTyGVVYKGR |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 12049736 |
Phosphorylation on tyrosine-15 of p34(cdc2) by erbb2 inhibits p34(cdc2) activation and is involved in resistance to taxol-induced apoptosis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Neratinib | down-regulates
chemical inhibition
|
ERBB2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202015 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 23632474 |
Ineratinib is a potent irreversible pan-erbb tyrosine kinase inhibitor that has demonstrated antitumour activity and an acceptable safety profile in patients with human epidermal growth factor receptor (her)-2-positive breast cancer and other solid tumours. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-194631 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ERBB2 | up-regulates quantity by expression 
transcriptional regulation
|
MSI1 |
0.03 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-165195 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 20443831 |
We investigated the possibilities that erbb2 may regulate downstream mediators of notch1 signaling to induce musashi1 (which enhances notch1 signaling). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Breast |
| + |
ERBB2 | up-regulates
binding
|
ERBB4 |
0.51 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-43844 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 8816440 |
Most breast, skin, lung, ovary, and gastrointestinal tract tumors express erbb-4, and heterodimerization of this receptor with erbb-2, may be involved in some cancer |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary, Lung |
| + |
NRG1 | up-regulates
binding
|
ERBB2 |
0.41 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-26875 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 7514177 |
Direct interaction between heregulin and the two proteins was demonstrated by chemical cross-linking experiments using 125i-heregulin followed by immunoprecipitation with antibodies specific for erbb2 or erbb3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Lapatinib Ditosylate | down-regulates
chemical inhibition
|
ERBB2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-177081 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 22056878 |
In estrogen-receptor-negative cellular models showing coamplification of erbb2 and rara, simultaneous targeting of the corresponding gene products with combinations of lapatinib and atra causes synergistic growth inhibition, cyto-differentiation and apoptosis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-193627 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
AZD8931 | down-regulates
chemical inhibition
|
ERBB2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163730 |
|
|
Homo sapiens |
Lung Cancer Cell |
| pmid |
sentence |
| 20145185 |
In vivo, azd8931 inhibited xenograft growth in a range of models while significantly affecting egfr, erbb2, and erbb3 phosphorylation and downstream signaling pathways, apoptosis, and proliferation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-190152 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
NOTCH1 | up-regulates quantity by expression
transcriptional regulation
|
ERBB2 |
0.07 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-145322 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 16554461 |
Notch1 activation by neuronal contact induces the glial expression of the brain lipid binding protein (blbp) and erbb2 genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Afatinib | down-regulates
chemical inhibition
|
ERBB2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196621 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 22418700 |
Afatinib is an oral, erbb family blocker, which covalently binds and irreversibly blocks all kinase-competent erbb family members. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-189359 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ERBB2 | up-regulates quantity by expression
transcriptional regulation
|
NOTCH3 |
0.03 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174747 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 21743488 |
We demonstrate that her2 overexpression in this cellular model of dcis drives transcriptional upregulation of multiple components of the notch survival pathway. Importantly, luminal filling required upregulation of a signaling pathway comprising notch3, its cleaved intracellular domain and the transcriptional regulator hes1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Canertinib dihydrochloride | down-regulates
chemical inhibition
|
ERBB2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191012 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CP-724714 | down-regulates
chemical inhibition
|
ERBB2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191103 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CUDC-101 | down-regulates
chemical inhibition
|
ERBB2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191148 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VARLITINIB | down-regulates
chemical inhibition
|
ERBB2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-189903 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AV412 | down-regulates
chemical inhibition
|
ERBB2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-190053 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Dacomitinib | down-regulates
chemical inhibition
|
ERBB2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-205939 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-200905 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23405260 |
The goal of this study was to compare dacomitinib (pf-00299804), a next generation small molecule tyrosine kinase inhibitor that irreversibly blocks multiple her family receptors (her-1 (egfr), her-2 and her-4 tyrosine kinases), to cetuximab, the current fda approved anti-egfr medication for hnscc and erlotinib, an egfr specific small molecule tyrosine kinase inhibitor. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
XL-647 | down-regulates
chemical inhibition
|
ERBB2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-207860 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197962 |
|
|
Homo sapiens |
Lung Cancer Cell |
| pmid |
sentence |
| 22722787 |
Xl647 is an oral small-molecule inhibitor of multiple receptor tyrosine kinases, including endothelial growth factor receptor (egfr), vascular endothelial growth factor receptor 2, her2 and ephrin type-b receptor 4 (ephb4). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
Arry-380 | down-regulates
chemical inhibition
|
ERBB2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-189882 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
873837-23-1 | down-regulates
chemical inhibition
|
ERBB2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-190470 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CBL | down-regulates quantity by destabilization
ubiquitination
|
ERBB2 |
0.08 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-30794 |
|
|
Homo sapiens |
Leukemia Cell, Lymphoma Cell |
| pmid |
sentence |
| 20332299 |
Ligand binding to EGFR also leads to rapid internalization and proteosomal/lysosomal degradation of the receptors. This process results in a dramatic downregulation of both total and cell surface receptors. EGF-induced degradation of EGFR is thought to be initiated by phosphorylation of tyrosine 1045 of the receptor followed by binding of Cbl adaptor proteins and ubiquitination of the receptor. Internalized EGFR is transported to early endosomes where receptor-ligand complexes are sorted for either degradation or recycling to the cell surface. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LRIG1 | down-regulates
ubiquitination
|
ERBB2 |
0.05 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-139948 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16123311 |
We report upregulation of lrig1 transcript and protein upon egf stimulation, and physical association of the encoded protein with the four egfr orthologs of mammals. Upregulation of lrig1 is followed by enhanced ubiquitylation and degradation of egfr. The underlying mechanism involves recruitment of c-cbl, an e3 ubiquitin ligase that simultaneously ubiquitylates egfr and lrig1 and sorts them for degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERBB2 | up-regulates
relocalization
|
SHC3 |
0.02 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-146855 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16729043 |
Erbb3 is characterized by a large number of binding sites for phosphatidylinositol-3-kinase (pi3k), while erbb2 has only few interaction partners with shc as the most frequent one. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERBB2 | up-regulates
binding
|
SHC1 |
0.14 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-65579 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10085134 |
Shc interacts with and is an excellent substrate for erbb2 and appears to play an important role in mitogenic signaling through this receptor tyrosine kinase |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGF | up-regulates
binding
|
ERBB2 |
0.34 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-106497 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11279155 |
To better understand the role of the egfr tyrosine kinase, we analyzed signaling by a kinase-inactive egfr (k721m) in erbb-devoid 32d cells. K721m alone exhibited no detectable signaling capacity, whereas coexpression of k721m with erbb2, but not erbb3 or erbb4, resulted in egf-dependent mitogen-activated protein kinase (mapk) activation. The kinase activity, but not tyrosine phosphorylation, of erbb2 was required for egf-induced mapk activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERBB2 | up-regulates
phosphorylation
|
ESR1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124962 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 15173068 |
The results presented here show for the first time that er redistribution to the cytoplasm and its interaction with her2 are important downstream effects of her2 overexpression, that erk1/2 is important for er cytoplasmic localization, and that subcellular localization of er may play a mechanistic role in determining the responsiveness of breast cancer cells to tamoxifen. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERBB2 | up-regulates
relocalization
|
GRB2 |
0.17 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-121968 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14967450 |
All erbb ligands and receptors couple to activation of the ras-mapk pathway, either directly through sh2 domain-mediated recruitment of grb-2 or indirectly through ptb domain-mediated binding of the shc adaptor |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Colorectal Carcinoma |
| + |
DTX1 | up-regulates quantity by expression
transcriptional regulation
|
ERBB2 |
0.02 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-145319 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16554461 |
Notch1-induced erbb2 expression in cerebellar astroglia occurs via dtx1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AREG | up-regulates
phosphorylation
|
ERBB2 |
0.09 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-31199 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7679104 |
Amphiregulin induces tyrosine phosphorylation of the epidermal growth factor receptor |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGFR | up-regulates
binding
|
ERBB2 |
0.90 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-106500 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11279155 |
These results demonstrate that egfr-erbb2 oligomers are potent activators of mapk and akt, and this signaling does not require egfr kinase activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERBB2 | up-regulates
binding
|
PLCG1 |
0.13 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-20815 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1676673 |
Activated egfr binds the sh2 domain of phospholipase c-gamma (plc-gamma), activating plc-gamma-mediated downstream signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LRIG3 | up-regulates
unknown
|
ERBB2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202180 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23723069 |
Lrig3 opposes lrig1 negative regulatory activity and stabilizes erbb receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LRIG1 | down-regulates 
unknown
|
ERBB2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202143 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23723069 |
Lrig1 is a negative regulator of oncogenic receptor tyrosine kinases, including erbb and met receptors, and promotes receptor degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERRFI1 | down-regulates activity
binding
|
ERBB2 |
0.05 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252077 |
|
|
in vitro |
|
| pmid |
sentence |
| 18046415 |
The cytoplasmic protein MIG6 (mitogen-induced gene 6; also known as ERRFI1) interacts with and inhibits the kinase domains of EGFR and ERBB2 |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
AEE 788 | down-regulates
chemical inhibition
|
ERBB2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-189347 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERBB2 | up-regulates
binding
|
ERBB3 |
0.81 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99569 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12648465 |
Although ErbB-2 binds no known ligand, when recruited into heterodimers it increases ligand binding affinity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-43841 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8816440 |
Although erbb-2 binds neither ligand, even in a heterodimeric receptor complex, it is the preferred heterodimer partner of the three other members, and it favors interaction with erbb-3. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ERBB2 | up-regulates
binding
|
EGFR |
0.90 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147838 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8816440 |
Although erbb-2 binds neither ligand, even in a heterodimeric receptor complex, it is the preferred heterodimer partner of the three other members, and it favors interaction with erbb-3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-43838 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8816440 |
Although erbb-2 binds neither ligand, even in a heterodimeric receptor complex, it is the preferred heterodimer partner of the three other members, and it favors interaction with erbb-3. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
Mubritinib | down-regulates
chemical inhibition
|
ERBB2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-194581 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
ERBB2
- 
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