Summary

Name ERBB2
Full Name Receptor tyrosine-protein kinase erbB-2
Synonyms Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2 | HER2, MLN19, NEU, NGL
Primary ID P04626
Links - -
Type protein
Relations 90
Pathways Colorectal Carcinoma, GPCR_CRC
Inhibitors neratinib; sapitinib; XL-647; 9-(1-Methyl-4-pyrazolyl)-1-[1-(1-oxoprop-2-enyl)-2,3-dihydroindol-6-yl]-2-benzo[h][1,6]naphthyridinone; canertinib; afatinib; dacomitinib; lapatinib; 6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine; AV412; VARLITINIB; 873837-23-1; CUDC-101; Mubritinib; 2-methoxy-N-[3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide; Arry-380
Function Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation ERBB2 0.402
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ERBB2 0.2
Publications: 4 Organism: Homo Sapiens, In Vitro
Pathways:Colorectal Carcinoma
+ down-regulates img/direct_inhibition.png dephosphorylation ERBB2 0.838
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png dephosphorylation ERBB2 0.67
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ERBB2 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
Pathways:Colorectal Carcinoma
+ down-regulates activity img/direct_inhibition.png dephosphorylation ERBB2 0.617
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ERBB2 0.2
Publications: 4 Organism: Homo Sapiens
Tissue: Breast
Pathways:Colorectal Carcinoma
+ up-regulates activity img/direct-activation.png phosphorylation EGFR 0.612
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation ERBB2 0.268
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png dephosphorylation ERBB2 0.404
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ERBB2 0.612
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation ERBB2 0.29
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation DOCK7 0.528
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDK1 0.274
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation BBC3 0.282
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTK2 0.656
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ERBB2 0.612
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EGFR 0.612
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2 0.8
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png ERBB2 0.404
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ERBB3 0.586
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination, ubiquitination ERBB2 0.625
Publications: 2 Organism: In Vitro, Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2 0.8
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2 0.8
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition ERBB2 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition ERBB2 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition ERBB2 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition ERBB2 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2 0.8
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2 0.8
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage ERBB2 0.345
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization GRB2 0.85
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma
+ down-regulates activity img/direct_inhibition.png binding ERBB2 0.71
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MSI1 0.266
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png ERBB2 0.306
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ERBB2 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ERBB2 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ERBB2 0.791
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ERBB2 0.626
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOTCH3 0.404
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition ERBB2 0.8
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ERBB2 0.497
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ERBB3 0.586
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination ERBB2 0.604
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition ERBB2 0.8
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ERBB2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination ERBB2 0.404
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BBC3 0.282
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FASN 0.444
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PLCG1 0.647
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ESR1 0.575
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation ERBB2 0.305
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition ERBB2 0.8
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization SHC3 0.547
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png deacetylation hsa-miR-139-5p 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ERBB2 0.791
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding ERBB4 0.527
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ErbB receptor family 0.626
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png binding SHC1 0.807
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation ERBB2 0.333
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding ERBB2 0.4
Publications: 1 Organism: Homo Sapiens