Summary

Name PTK2
Full Name Focal adhesion kinase 1
Synonyms FADK 1, Focal adhesion kinase-related nonkinase, FRNK, Protein phosphatase 1 regulatory subunit 71, PPP1R71, Protein-tyrosine kinase 2, p125FAK, pp125FAK | FAK, FAK1
Primary ID Q05397
Links - -
Type protein
Relations 115
Pathways Axon guidance, Integrin Signaling, VEGF Signaling
Inhibitors N-methyl-N-[3-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]methanesulfonamide; PF-03814735
Function Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation PTK2 0.314
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTK2 0.275
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ up-regulates activity img/direct-activation.png phosphorylation ATP2B4 (isoform 6) 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation, binding PXN 0.912
Publications: 3 Organism: Homo Sapiens
Pathways:Integrin Signaling, VEGF Signaling
+ down-regulates img/direct_inhibition.png phosphorylation ACTN1 0.551
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ down-regulates activity img/direct_inhibition.png phosphorylation ACTN1 0.551
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:Axon guidance
+ img/unknown.png phosphorylation CTNNB1 0.419
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation PTK2 0.471
Publications: 8 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTK2 0.533
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTK2 0.577
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTK2 0.403
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ACTN4 0.539
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TRIO 0.481
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png phosphorylation ACTN4 0.539
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation SH3GL1 0.405
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation PTK2 0.814
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation PTK2 0.357
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation PTK2 0.721
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTK2 0.2
Publications: 8 Organism: Homo Sapiens
Tissue: Kidney
Pathways:Axon guidance, Integrin Signaling, VEGF Signaling
+ up-regulates img/direct-activation.png phosphorylation PTK2 0.629
Publications: 8 Organism: Homo Sapiens
Pathways:Axon guidance, Integrin Signaling
+ down-regulates activity img/direct_inhibition.png dephosphorylation PTK2 0.559
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png dephosphorylation PTK2 0.246
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PTK2 0.497
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SHC1 0.659
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTK2 0.36
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PTK2 0.616
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTK2 0.525
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation PTK2 0.246
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png dephosphorylation PTK2 0.719
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation BCAR1 0.805
Publications: 2
+ up-regulates img/direct-activation.png phosphorylation RET 0.616
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTK2 0.527
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PTK2 0.704
Publications: 2 Organism: Homo Sapiens
Pathways:Axon guidance
+ up-regulates activity img/direct-activation.png binding GRB2 0.692
Publications: 1
Pathways:Integrin Signaling, VEGF Signaling
+ up-regulates activity img/indirect-activation.png PTK2 0.549
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PTK2 0.649
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ up-regulates activity img/indirect-activation.png PTK2 0.544
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PTK2 0.6
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PTK2 0.457
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PTK2 0.549
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TLN1 0.674
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ up-regulates activity img/indirect-activation.png PTK2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png PTK2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PTK2 0.444
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PTK2 0.55
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PTK2 0.575
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PTK2 0.467
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png PTK2 0.532
Publications: 1
+ up-regulates activity img/indirect-activation.png PTK2 0.566
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ up-regulates activity img/indirect-activation.png PTK2 0.593
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PTK2 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PTK2 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTK2 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ up-regulates activity img/indirect-activation.png PTK2 0.696
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PTK2 0.427
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png PTK2 0.471
Publications: 1 Organism: Mus Musculus
Pathways:VEGF Signaling
+ up-regulates activity img/indirect-activation.png PTK2 0.558
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ down-regulates activity img/direct_inhibition.png binding PTK2 0.551
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:Axon guidance
+ down-regulates img/direct_inhibition.png dephosphorylation PTK2 0.559
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PTK2 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/indirect-activation.png PTK2 0.666
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ up-regulates activity img/indirect-activation.png PTK2 0.462
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PTK2 0.542
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PTK2 0.559
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PTK2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PI3K 0.547
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling, VEGF Signaling
+ up-regulates activity img/indirect-activation.png PTK2 0.445
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PTK2 0.584
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PTK2 0.618
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PTK2 0.532
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PTK2 0.536
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PTK2 0.437
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PTK2 0.439
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PTK2 0.493
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ up-regulates activity img/indirect-activation.png PTK2 0.616
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PTK2 0.629
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PTK2 0.575
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PTK2 0.564
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png PTK2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation PTK2 0.357
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png PTK2 0.558
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signaling
+ up-regulates img/direct-activation.png binding PIK3R1 0.531
Publications: 1 Organism: Homo Sapiens