FAP: Insulin-mediated adipogenesis

Pathway ID: SIGNOR-FapINSView in NDEx

Description: Insulin pro-adipogenic effects are mainly mediated through the PI3K/AKT pathway, which is responsible for the phosphorylation and subsequent nuclear exclusion of anti-adipogenic transcription factors, such as the forkhead proteins FOXO1 and FOXA2. Another target of AKT-mediated modulation is GATA2 that exerts its anti-adipogenic activity through direct inhibition of several adipogenic factors, including PPARγ.

Curated by: Andrea Cerquone Perpetuini

complexity level

level 1 seed interactions
level 2 connect
level 3 first neighbors
level 4 all
level 5 PPI

12 Seed Entities

Organism:
Name Primary ID
DLK1 P80370
GATA2 P23769
INSR P06213
INS P01308
FOXA2 Q9Y261
PI3K SIGNOR-C156
Adipogenesis SIGNOR-PH26
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate CHEBI:16618
FOXO1 Q12778
PPARG P37231
PDPK1 O15530
AKT SIGNOR-PF24