FAP: SIRT1

Pathway ID: SIGNOR-FapSIR

Description: SIRT1 (sirtuin 1) was originally identified as a NAD-dependent histone deacetylase that inhibits adipogenesis. The interaction between Sirt1 and NCOR represses PPARγ activity by docking with its cofactors. SIRT1 inhibition of adipogenesis is also mediated by the deacetylation of beta catenin (CTNNB1).

Curated by: Federica Ferrentino

9 Seed Entities

Organism:
Name Primary ID
NCOR2 Q9Y618
PPARG P37231
Adipogenesis SIGNOR-PH26
SRT1720 CID:25232708
SIRT1 Q96EB6
CTNNB1 P35222
FOXO1 Q12778
NCOR1 O75376
resveratrol CHEBI:27881