Summary

Name NCOR1
Full Name Nuclear receptor corepressor 1
Synonyms N-CoR, N-CoR1 | KIAA1047
Primary ID O75376
Links - -
Type protein
Relations 6
Pathways FAP: SIRT1
Function Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation NCOR1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NCOR1 0.436
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation PPARG 0.696
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SNAI2 0.362
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BCL6 0.586
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png NCOR1 0.641
Publications: 1 Organism: Homo Sapiens