3.0
Mast cell: SCF
Pathway ID: SIGNOR-MastSCF
Description: The most important mast cell growth factor is SCF, which is the ligand of KIT receptor expressed on mast cell membrane surface. SCF-KIT pathway is linked to survival, proliferation and chemotaxis of mast cells, via distinct pathways, which involve MAPKs, ERK and STATs transcription factors.
Curated by: Alessandro Palma
Description: The most important mast cell growth factor is SCF, which is the ligand of KIT receptor expressed on mast cell membrane surface. SCF-KIT pathway is linked to survival, proliferation and chemotaxis of mast cells, via distinct pathways, which involve MAPKs, ERK and STATs transcription factors.
Curated by: Alessandro Palma
12 Seed Entities
Organism: 
|
Name | Primary ID |
|---|---|
| SRC_kinase_family | SIGNOR-PF32 |
| KITLG | P21583 |
| BAD | Q92934 |
| Proliferation | SIGNOR-PH4 |
| Chemotaxis | SIGNOR-PH93 |
| AKT | SIGNOR-PF24 |
| ERK1/2 | SIGNOR-PF1 |
| STAT5A | P42229 |
| JAK2 | O60674 |
| Survival | SIGNOR-PH13 |
| KIT | P10721 |
| PI3K | SIGNOR-C156 |