| + |
AKT1 | up-regulates 
phosphorylation
|
SP7 |
0.435 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252514 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21619873 |
Akt, a member of the ser-ine/threonine-specific protein kinase, was found to phosphorylate osx and dlx5 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195549 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21777568 |
We found that Akt phosphorylates Osterix and that Akt activation increases protein stability, osteogenic activity and transcriptional activity of Osterix. We also found that BMP-2 increases the protein level of Osterix in an Akt activity-dependent manner. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SP7 | up-regulates 
|
Osteoblast_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255449 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11792318 |
Our results established that the novel transcription factor Osx is required for osteoblast differentiation and hence for bone formation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
RUNX2 | up-regulates
transcriptional regulation
|
SP7 |
0.526 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255410 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16574347 |
Osx promoter activity was up-regulated by 2 fold after Runx2 over-expression in ATDC5 cells. Osx Is Phosphorylated by p38 at Ser-73 and Ser-77 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SP7 | up-regulates quantity by expression
transcriptional regulation
|
IFITM5 |
0.374 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254219 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23530031 |
Regulation of the bone-restricted IFITM-like (Bril) gene transcription by Sp and Gli family members and CpG methylation. Bril transcription is activated by Sp1, Sp3, OSX, and GLI2 and by CpG demethylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT | up-regulates
phosphorylation
|
SP7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174017 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21777568 |
We found that Akt phosphorylates Osterix and that Akt activation increases protein stability, osteogenic activity and transcriptional activity of Osterix. We also found that BMP-2 increases the protein level of Osterix in an Akt activity-dependent manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
SP7 |
0.419 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255791 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20682789 |
We therefore propose that Osterix binds to Sp1 sequences on target gene promoters and that its phosphorylation by p38 enhances recruitment of coactivators to form transcriptionally active complexes |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SP7 | up-regulates quantity by expression
transcriptional regulation
|
BGLAP |
0.507 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255409 |
|
|
Mus musculus |
C3H10T1/2 Cell, C2C12 Cell |
| pmid |
sentence |
| 11792318 |
To test whether Osx could activate typical osteoblast genes, we transfected an Osx expressing vector into both C2C12 and C3H10T1/2 cells. Our results showed that Osx produced an induction of osteocalcin RNA in both cell types. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
SP7
- 
- 