Parkinson disease

Pathway ID: SIGNOR-PDView in NDEx

Description: Parkinson disease (PD) is a neurodegenerative disorder, whose clinical manifestations include resting tremor, muscular rigidity and akinesia. PD is associated to the selective degeneration and death of dopaminergic neurons and is characterized by the deposition of abnormal protein aggregates called “Lewy bodies” in the surviving dopaminergic neurons. Alpha-synuclein is a major protein component of Lewy bodies and is found to be mutated or over-expressed in patients with PD. Other proteins that have been found to be mutated or over-expressed in PD are: Parkin, it is an E3 ubiquitin ligase that, in normal condition, ubiquitinates alpha-synuclein with its consequent proteasome-dependent degradation, mutations in Parkin gene lead to accumulation of alpha-synuclein; UCH-L1 is an Ubiquitin hydrolase that generates Ubiquitin monomers, necessary for the degradation of alpha-synuclein, mutant forms of UCH-L1 result in accumulation of alpha-synuclein; Mutations in DNAJC14 genes are associated with increased level of oxidative stress that predispose neurons to precipitate alpha-synuclein.

Curated by: Livia Perfetto

complexity level

level 1 seed interactions
level 2 connect
level 3 first neighbors
level 4 all
level 5 PPI

18 Seed Entities

Organism:
Name Primary ID
AKT1 P31749
Apoptosis SIGNOR-PH2
CASP3 P42574
CASP9 P55211
CYCS P99999
DNAJC14 Q6Y2X3
ER stress SIGNOR-ST9
HTRA2 O43464
Lewy body formation SIGNOR-PH56
LRRK2 Q5S007
MTOR P42345
PINK1 Q9BXM7
PRKN O60260
ROS SIGNOR-ST2
SNCA P37840
UBC P0CG48
UCHL1 P09936
XIAP P98170