| + |
nitric oxide | up-regulates activity 
chemical activation
|
GUCY1A2-B2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243961 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15036565 |
One of the most biologically relevant actions of NO is its binding to the heme moiety in the heterodimeric enzyme, soluble guanylyl cyclase (sGC). Activation of sGC by NO results in the production of the second messenger molecule, 3²,5²-cyclic guanosine monophosphate (cGMP) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MTARC1 | up-regulates quantity
chemical modification
|
nitric oxide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261419 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24500710 |
our results indicate that mARC can generate nitric oxide (NO) from nitrite when forming an electron transfer chain with NADH, cytochrome b5, and NADH-dependent cytochrome b5 reductase. expression of mARC-1 in HEK cells using a lentivirus vector was used to confirm cellular nitrite reduction to NO. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOS2 | up-regulates 
|
nitric oxide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255381 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7537672 |
Activation with lipopolysaccharide induces macrophages to produce the enzymes arginase and nitric oxide (NO) synthase. Both enzymes use as a substrate the ammino acid L-arginine, which can be either hydrolyzed by arginase to urea and ornithine or oxidized by NO synthase to NO and citrulline |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
nitric oxide | up-regulates
|
Vascular_Permeability |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261947 |
|
|
Homo sapiens |
Endothelial Cell |
| pmid |
sentence |
| 24078390 |
After a period of controversial reports, evidence based on eNOS knockout mice and on eNOS-depleted EC established that microvascular hyperpermeability in response to an inflammatory challenge is regulated mainly by endothelial cells through eNOS-derived NO |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | VEGF Signaling |
| + |
NOS3 | up-regulates quantity
chemical modification
|
nitric oxide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251629 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24379783 |
Nitric oxide (NO) is a major mediator of endothelial function and is synthesized in endothelial cells by endothelial nitric oxide synthase (eNOS). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | VEGF Signaling |
| + |
nitric oxide | up-regulates
|
NfKb-p65/p50 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255350 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20219869 |
Similarly, exposure of cells to oxidative stress, in particular, nitric oxide (NO) or peroxynitrite (ONOO), can activate NF-kB and cause its translocation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | Multiple sclerosis |
| + |
nitric oxide | up-regulates activity
chemical activation
|
GUCY1A2-B3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243964 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15036565 |
One of the most biologically relevant actions of NO is its binding to the heme moiety in the heterodimeric enzyme, soluble guanylyl cyclase (sGC). Activation of sGC by NO results in the production of the second messenger molecule, 3²,5²-cyclic guanosine monophosphate (cGMP) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
nitric oxide | up-regulates
|
Demyelination |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263829 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32454942 |
Next to their interaction with adaptive immune cells, activated microglia can secrete cytotoxic cytokines and oxidative products, such as ROS and NO radicals in MS lesions thereby promoting oxidative stress and contributing to myelin destruction |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Multiple sclerosis |
| + |
nitric oxide | up-regulates
|
ROS |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272279 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35681445 |
The ROS, including superoxide anion, hydrogen peroxide, and nitric oxide, play both beneficial and detrimental roles depending upon their levels and cellular microenvironment. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Multiple sclerosis |
| + |
nitric oxide | up-regulates activity
chemical activation
|
GUCY1A3-B2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244113 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15036565 |
One of the most biologically relevant actions of NO is its binding to the heme moiety in the heterodimeric enzyme, soluble guanylyl cyclase (sGC). Activation of sGC by NO results in the production of the second messenger molecule, 3²,5²-cyclic guanosine monophosphate (cGMP) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
nitric oxide | up-regulates activity
|
DNM1L |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275650 |
|
|
|
|
| pmid |
sentence |
| 33850055 |
Upon viral infection, DDAH2 relocated to mitochondria, where it induced the production of nitric oxide (NO) and the activation of dynamin-related protein 1 (Drp1) |
|
| Publications: |
1 |
| + |
nitric oxide | up-regulates
|
M1_polarization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255556 |
|
|
|
|
| pmid |
sentence |
| 24669294 |
While investigating the factors that regulate macrophage arginine metabolism, Mills and colleagues found that macrophages activated in mouse strains with Th1 and Th2 backgrounds differed qualitatively in their ability to respond to the classic stimuli IFN-γ or lipopolysaccharide (LPS) or both and defined an important metabolic difference in the pathway: M1 macrophages made the toxic nitric oxide (NO), whereas M2 macrophages made the trophic polyamines |
|
| Publications: |
1 |
| Pathways: | Multiple sclerosis |
| + |
NOS1 | up-regulates quantity
chemical modification
|
nitric oxide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243957 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21890489 |
Nitric oxide (NO), the smallest signalling molecule known, is produced by three isoforms of NO synthase (NOS; EC 1.14.13.39). They all utilize l-arginine and molecular oxygen as substrates |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
nitric oxide | up-regulates activity
chemical activation
|
GUCY1A3-B3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243967 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15036565 |
One of the most biologically relevant actions of NO is its binding to the heme moiety in the heterodimeric enzyme, soluble guanylyl cyclase (sGC). Activation of sGC by NO results in the production of the second messenger molecule, 3²,5²-cyclic guanosine monophosphate (cGMP) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DDAH2 | up-regulates quantity
|
nitric oxide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275649 |
|
|
|
|
| pmid |
sentence |
| 33850055 |
Upon viral infection, DDAH2 relocated to mitochondria, where it induced the production of nitric oxide (NO) and the activation of dynamin-related protein 1 (Drp1) |
|
| Publications: |
1 |
3.0
nitric oxide