| + |
WWP2 | down-regulates quantity 
ubiquitination
|
EGR2 |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268849 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19651900 |
The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination|AIP2 interacts with and promotes ubiquitin-mediated degradation of EGR2, a zinc finger transcription factor that has been found to regulate Fas ligand (FasL) expression during activation-induced T-cell death. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWP2 | down-regulates quantity
ubiquitination
|
SLC11A2 |
0.304 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268852 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 18776082 |
Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2|This promotes DMT1 ubiquitination and degradation by WWP2. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
WWP2 | down-regulates quantity by destabilization
polyubiquitination
|
ABI3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272656 |
|
|
in vitro |
|
| pmid |
sentence |
| 15998807 |
The AIP2 E3 ligase acts as a novel negative regulator of ABA signaling by promoting ABI3 degradation. Here, we show that ABI3 is an unstable protein and that an ABI3-interacting protein (AIP2), which contains a RING motif, can polyubiquitinate ABI3 in vitro. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
WWP2 | down-regulates quantity by destabilization
ubiquitination
|
PAIP1 |
0.338 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272842 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25266661 |
Here, we show that the E6AP carboxyl terminus (HECT)-type ubiquitin ligase WW domain-containing protein 2 (WWP2), a homolog of the HECT-type ubiquitin ligase WWP1, interacts with and targets Paip1 for ubiquitination and proteasomal degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Ub:E2 | up-regulates activity 
ubiquitination
|
WWP2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271288 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWP2 | down-regulates quantity by destabilization
polyubiquitination
|
TP73 |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272233 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25071155 |
WWP2 ubiquitinates p73 and controls its protein stability. In our study, we identified WWP2, an E3 ligase, as a novel p73-associated protein that ubiquitinates and degrades p73. In contrast, WWP2 heterodimerizes with another E3 ligase, WWP1, which specifically ubiquitinates and degrades ΔNp73. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWP2 | up-regulates activity
binding
|
WWP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272231 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25071155 |
WWP1 in complex with WWP2 specifically regulates ΔNp73. In our study, we identified WWP2, an E3 ligase, as a novel p73-associated protein that ubiquitinates and degrades p73. In contrast, WWP2 heterodimerizes with another E3 ligase, WWP1, which specifically ubiquitinates and degrades ΔNp73. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWP2 | down-regulates quantity
ubiquitination
|
POLR2A |
0.396 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268851 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 31048545 |
WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks|In response to DSBs, WWP2 targets the RNAPII subunit RPB1 for K48-linked ubiquitylation, thereby driving DNA-PK- and proteasome-dependent eviction of RNAPII. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WWP2 | down-regulates quantity
ubiquitination
|
POU5F1 |
0.465 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268850 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19274063 |
WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells|Here, we report that human WWP2, an E3 ubiquitin (Ub)-protein ligase, interacts with OCT4 specifically through its WW domain and enhances Ub modification of OCT4 both in vitro and in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
WWP2
- 
- 