Summary

Name SPAG9
Full Name C-Jun-amino-terminal kinase-interacting protein 4
Synonyms JIP-4, JNK-interacting protein 4, Cancer/testis antigen 89, CT89, Human lung cancer oncogene 6 protein, HLC-6, JNK-associated leucine-zipper protein, JLP, Mitogen-activated protein kinase 8-interacting protein 4, Proliferation-inducing protein 6, Protein highly expressed in testis, PHET, Sperm surface protein, Sperm-associated antigen 9, Sperm-specific protein, Sunday driver 1 | HSS, KIAA0516, MAPK8IP4, SYD1
Primary ID O60271
Links - -
Type protein
Relations 8
Pathways P38 Signaling and Myogenesis
Function The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ SPAG9up-regulates activity img/direct-activation.png binding MAPK14 0.542
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ CDONup-regulates activity img/direct-activation.png binding SPAG9 0.477
Publications: 2 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ SPAG9 img/unknown.png binding ABL1 0.506
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ SPAG9 img/unknown.png binding MAP3K5 0.363
Publications: 1 Organism: Mus Musculus
Pathways:P38 Signaling and Myogenesis
+ SPAG9form complex img/form-complex.png binding CDON/SPAG9 0.477
Publications: 1 Organism: Homo Sapiens
+ SPAG9up-regulates img/direct-activation.png binding MAPK11 0.421
Publications: 1 Organism: Homo Sapiens
+ SPAG9 img/unknown.png binding MAP3K7 0.2
Publications: 1 Organism: Mus Musculus
Pathways:P38 Signaling and Myogenesis