Summary

Name ERN1
Full Name Serine/threonine-protein kinase/endoribonuclease IRE1
Synonyms Endoplasmic reticulum-to-nucleus signaling 1, Inositol-requiring protein 1, hIRE1p, Ire1-alpha, IRE1a | IRE1
Primary ID O75460
Links - -
Type protein
Relations 4
Function Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation (PubMed:9637683, PubMed:11175748, PubMed:12637535). The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis (PubMed:24508390).

Viewer

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png unknown ERN1 0.36
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding ERN1 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown JUN 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown ERN1 0.14
Publications: 1 Organism: Homo Sapiens