Summary
Name | ERN1 View Modifications |
Full Name | Serine/threonine-protein kinase/endoribonuclease IRE1 |
Synonyms | Endoplasmic reticulum-to-nucleus signaling 1, Inositol-requiring protein 1, hIRE1p, Ire1-alpha, IRE1a | IRE1 |
Primary ID | O75460 |
Links | - - |
Type | protein |
Relations | 13 |
Pathways | COVID-19 Causal Network, SARS-CoV ER STRESS |
Function | Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11779464, PubMed:11175748, PubMed:12637535, PubMed:9637683, PubMed:21317875, PubMed:28128204). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875). Accumulation of misfolded proteins in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:24508390, PubMed:21317875). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464, PubMed:24508390, PubMed:21317875). Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed:21884936, PubMed:28067262). |
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Modifications Tables
Relations
Regulator | Mechanism | target | score ℹ | |
---|---|---|---|---|
+ | ERN1 | up-regulates activity phosphorylation | ERN1 | 0.2 |
Publications: | 1 | Organism: | In Vitro | |
Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS | |||
+ | Unfolded_Proteins | up-regulates | ERN1 | 0.7 |
Publications: | 1 | Organism: | Homo Sapiens | |
Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS | |||
+ | ER stress | up-regulates | ERN1 | 0.7 |
Publications: | 1 | Organism: | Homo Sapiens | |
Pathways: | COVID-19 Causal Network | |||
+ | ERN1 | up-regulates activity binding | TRAF2 | 0.668 |
Publications: | 1 | Organism: | Mus Musculus | |
+ | E | down-regulates activity | ERN1 | 0.2 |
Publications: | 1 | Organism: | Chlorocebus Aethiops | |
Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS | |||
+ | DAB2IP | up-regulates activity binding | ERN1 | 0.375 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | ERN1 | up-regulates | JUN | 0.39 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | PDIA6 | down-regulates activity | ERN1 | 0.32 |
Publications: | 1 | Organism: | Mus Musculus | |
+ | ERN1 | up-regulates quantity by expression post transcriptional regulation | XBP1 (isoform 2) | 0.631 |
Publications: | 1 | Organism: | Homo Sapiens | |
Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS | |||
+ | HSPA5 | down-regulates activity binding | ERN1 | 0.812 |
Publications: | 1 | Organism: | Homo Sapiens | |
Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS | |||
+ | ERN1 | down-regulates activity | JNK | 0.32 |
Publications: | 1 | Organism: | Homo Sapiens | |
Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS | |||
+ | ERN1 | up-regulates quantity by expression transcriptional regulation | OS9 | 0.436 |
Publications: | 1 | Organism: | Homo Sapiens | |
+ | SOD1 | up-regulates activity binding | ERN1 | 0.319 |
Publications: | 1 | Organism: | Mus Musculus | |