Summary

Name IL6R
Full Name Interleukin-6 receptor subunit alpha
Synonyms IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, IL-6R 1, Membrane glycoprotein 80, gp80
Primary ID P08887
Links - -
Type protein
Relations 8
Pathways IL6 Signaling, Macrophage: IL6, Macrophage: Polarization and myogenesis, Multiple sclerosis, Myoblast: IL6 and hypertrophy, Myofiber: IL6 and atrophy, SARS-CoV CYTOKINE STORM, Satellite: IL6, T-Lymphocyte: IL6
Function Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal (PubMed:28265003). Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis (Probable). The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable).

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Relations

Regulator Mechanism target score ℹ
+ IL6Rup-regulates activity img/direct-activation.png phosphorylation JAK2 0.551
Publications: 1 Organism: Homo Sapiens
+ Tocilizumabdown-regulates activity img/direct_inhibition.png binding IL6R 0.4
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ IL6Rup-regulates img/direct-activation.png binding IL6ST 0.736
Publications: 2 Organism: Homo Sapiens
Pathways:IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ IL6up-regulates img/direct-activation.png binding IL6R 0.916
Publications: 3 Organism: Homo Sapiens
Tissue: Brain, Muscle, Skeletal Muscle
Pathways:IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ IL6up-regulates activity img/direct-activation.png binding IL6R 0.916
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM