| + |
SGK1 | up-regulates activity 
phosphorylation
|
SLC2A4 |
0.318 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236653 |
Ser274 |
LERERPLsLLQLLGS |
Xenopus laevis |
|
| pmid |
sentence |
| 17382906 |
We evaluated the putative role of sgk1 in the modulation of glut4. Coexpression of the kinase along with glut4 in xenopus oocytes stimulated glucose transport. The enhanced glut4 activity was paralleled by increased transporter abundance in the plasma membrane. Disruption of the sgk1 phosphorylation site on glut4 ((s274a)glut4) abrogated the stimulating effect of sgk1. In summary, sgk1 promotes glucose transporter membrane abundance via glut4 phosphorylation at ser274. |
|
| Publications: |
1 |
Organism: |
Xenopus Laevis |
| Tissue: |
Muscle |
| Pathways: | Insulin Signaling |
| + |
AKT1 | up-regulates 
|
SLC2A4 |
0.566 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252580 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9415393 |
Akt is not only capable of stimulating the translocation of glut4 to the cell surface. Endogenous akt is likely to play a significant physiological role in insulin-stimulated glucose uptake in insulin targets such as muscle and adipose tissue |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INS | up-regulates activity
|
SLC2A4 |
0.512 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236781 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9415393 |
Studies in adipose cells have demonstrated that insulin stimulates its receptor to phosphorylate tyrosine residues in irs-1, leading to activation of phosphatidylinositol 3-kinase, which plays a necessary role in mediating the translocation of the insulin-responsive glucose transporter glut4 to the cell surface. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| Pathways: | Insulin Signaling |
| + |
PRKAA1 | up-regulates quantity by expression
transcriptional regulation
|
SLC2A4 |
0.307 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156786 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17609368 |
Several in vivo studies using aicar to activate ampk chronically determined that mitochondrial enzymes [e.g., cytochrome c, uncoupling protein 3 (ucp-3)] and proteins involved in glucose uptake (glut4)are increased at the transcriptional level in skeletal muscle. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RHOQ | up-regulates
|
SLC2A4 |
0.445 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-93117 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12242347 |
Tc10 is activated afte rinsulin stimulation, and its activation is required for insulin-stimulated glucose uptake and glut4 translocation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK1 | up-regulates
|
SLC2A4 |
0.341 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164286 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20231899 |
An erk pharmacological inhibitor, pd98059, and the pld inhibitor, 1-btoh, both attenuate (14)c-glucose uptake in muscle cells. Finally, the extracellular stresses caused by glucose deprivation or aminoimidazole carboxamide ribonucleotide (aicar;ampk activator) regulate (14)c-glucose uptake and cell surface glucose transport (glut) 4 through erk stimulation by ampk-mediated pld1 activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SLC2A4 | up-regulates quantity
relocalization
|
α-D-glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267291 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17403369 |
Skeletal muscle both stores glucose as glycogen and oxidizes it to produce energy following the transport step. The principal glucose transporter protein that mediates this uptake is GLUT4, which plays a key role in regulating whole body glucose homeostasis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
TBC1D4 | down-regulates 
|
SLC2A4 |
0.655 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99303 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12637568 |
These findings strongly indicate that insulin-stimulated phosphorylation of as160 is required for glut4 translocation and that this phosphorylation signals translocation through inactivation of the rab gap function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EXOC7 | up-regulates
|
SLC2A4 |
0.53 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100242 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12687004 |
So, the exocyst might have a crucial role in the targeting of the glut4 vesicle to the plasma membrane, perhaps directing the vesicle to the precise site of fusion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MEF2A | up-regulates quantity by expression
transcriptional regulation
|
SLC2A4 |
0.371 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271692 |
|
|
|
|
| pmid |
sentence |
| 14630949 |
Neither GEF nor MEF2A alone significantly activated GLUT4 promoter activity, but increased promoter activity 4- to 5-fold when expressed together. |
|
| Publications: |
1 |
| + |
AKT | up-regulates
|
SLC2A4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-45117 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8940145 |
The constitutively active Akt induced glucose uptake into adipocytes in the absence of insulin by stimulating translocation of the insulin-responsive glucose transporter 4 to the plasma membrane. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53968 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9415393 |
Akt is not only capable of stimulating the translocation of glut4 to the cell surface. Endogenous akt is likely to play a significant physiological role in insulin-stimulated glucose uptake in insulin targets such as muscle and adipose tissue |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis, Insulin Signaling |
| + |
SLC2A4 | up-regulates quantity
relocalization
|
glucose |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267288 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17403369 |
Skeletal muscle both stores glucose as glycogen and oxidizes it to produce energy following the transport step. The principal glucose transporter protein that mediates this uptake is GLUT4, which plays a key role in regulating whole body glucose homeostasis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARGC1A | up-regulates quantity by expression
transcriptional regulation
|
SLC2A4 |
0.613 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156769 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17609368 |
Pgc-1alpha protein is required for ampk action on glut4 gene expression and mitochondrial function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
TP53 | down-regulates quantity by repression 
transcriptional regulation
|
SLC2A4 |
0.343 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267465 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27692180 |
P53 regulates basal expression of AIF and SCO2 and facilitates oxidative phosphorylation. The expression of GLUT1, GLUT4, and HK2 is negatively regulated by p53, whereas TIGAR expression is induced by p53. The net result of p53-mediated regulation of these glycolytic enzymes is the suppression of glycolysis. In addition, p53 directly binds and inhibits G6PD activity and downregulates the pentose phosphate pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
3.0
SLC2A4
- 
- 