Summary

Name F2R
Full Name Proteinase-activated receptor 1
Synonyms PAR-1, Coagulation factor II receptor, Thrombin receptor | CF2R, PAR1, TR
Primary ID P25116
Links - -
Type protein
Relations 51
Inhibitors vorapaxar
Function High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png cleavage F2R 0.432
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png cleavage F2R 0.421
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png cleavage F2R 0.432
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png cleavage F2R 0.421
Publications: 4 Organism: In Vitro
+ up-regulates activity img/direct-activation.png cleavage F2R 0.887
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png cleavage F2R 0.624
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png cleavage F2R 0.582
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png cleavage F2R 0.624
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png cleavage F2R 0.377
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png cleavage F2R 0.377
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png cleavage F2R 0.887
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png cleavage F2R 0.582
Publications: 3 Organism: In Vitro
+ down-regulates img/indirect_inhibition.png LATS1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png , binding GNA13 0.597
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation THBS1 0.303
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA12 0.563
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA14 0.436
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RAB3A 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition F2R 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/indirect_inhibition.png LATS1/2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SDC4 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNA12 0.563
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNAI1 0.399
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TNFRSF12A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FOSL1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAZ 0.445
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAQ 0.58
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.399
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation F2R 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png cleavage, binding F2R 0.887
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CD44 0.25
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAO1 0.421
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI3 0.398
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation F2R 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KLF6 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png LATS2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA15 0.565
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CORO1C 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation F2R 0.8
Publications: 1 Organism: Homo Sapiens