Summary

Name FUS
Full Name RNA-binding protein FUS
Synonyms 75 kDa DNA-pairing protein, Oncogene FUS, Oncogene TLS, POMp75, Translocated in liposarcoma protein | TLS
Primary ID P35637
Links - -
Type protein
Relations 31
Function DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png sumoylation PA2G4 0.342
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png post transcriptional regulation CSDE1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/indirect-activation.png Protein_aggregates 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization MATR3 0.506
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png post transcriptional regulation SHANK1 0.2
Publications: 1 Organism: Mus Musculus
Tissue: Brain
+ up-regulates quantity img/direct-activation.png post transcriptional regulation DLG4 0.275
Publications: 1 Organism: Mus Musculus
Tissue: Brain
+ up-regulates activity img/direct-activation.png relocalization GEMIN6 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding FUS 0.536
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Protein_synthesis 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png FUS 0.3
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization DHX9 0.456
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png methylation FUS 0.504
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png post transcriptional regulation GRIA4 0.2
Publications: 1 Organism: Mus Musculus
Tissue: Spinal Cord
+ down-regulates quantity by repression img/indirect_inhibition.png post transcriptional regulation DUSP22 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png relocalization DDX3X 0.26
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png post transcriptional regulation AMPA 0.288
Publications: 1 Organism: Mus Musculus
Tissue: Spinal Cord
+ down-regulates quantity by repression img/indirect_inhibition.png post transcriptional regulation MPHOSPH9 0.2
Publications: 1 Organism: Mus Musculus
Tissue: Spinal Cord
+ down-regulates quantity by repression img/indirect_inhibition.png post transcriptional regulation ADARB1 0.258
Publications: 1 Organism: Mus Musculus
Tissue: Spinal Cord
+ up-regulates activity img/direct-activation.png relocalization FUS 0.664
Publications: 1 Organism: In Vitro
+ down-regulates activity img/indirect_inhibition.png relocalization FUS 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization SMN1 0.384
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png post transcriptional regulation HNRNPA2B1 0.488
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png relocalization GEMIN4 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SNRNP70 0.442
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png relocalization FUS 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png post transcriptional regulation AGRN 0.278
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png post transcriptional regulation ATXN2 0.474
Publications: 1 Organism: Mus Musculus
Tissue: Spinal Cord
+ up-regulates activity img/direct-activation.png relocalization FUS 0.234
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization FUS 0.375
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png post transcriptional regulation VPS16 0.2
Publications: 1 Organism: Mus Musculus
Tissue: Spinal Cord