3.0
Summary
| Name |  FOXL2View Modifications |
| Full Name | Forkhead box protein L2 |
| Synonyms | FOXL2_HUMAN |
| Primary ID | P58012 |
| Links |  -  -  |
| Type | protein |
| Relations | 11 |
| Function | Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | UBE2I | up-regulates 
sumoylation
|
FOXL2 | 0.684 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SIRT1 | down-regulates 
deacetylation
|
FOXL2 | 0.518 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FOXL2 | up-regulates 
|
Cell_death | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Ovary | |||
| + | ROS | up-regulates quantity by expression
transcriptional regulation
|
FOXL2 | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FOXL2 | up-regulates quantity by expression
transcriptional regulation
|
SIRT1 | 0.518 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FOXL2 | down-regulates quantity by repression 
transcriptional regulation
|
CCND2 | 0.407 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FOXL2 | down-regulates quantity by repression
transcriptional regulation
|
CYP19A1 | 0.522 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FOXL2 | down-regulates quantity by repression
transcriptional regulation
|
CYP11A1 | 0.404 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FOXL2 | down-regulates quantity by repression
transcriptional regulation
|
STAR | 0.372 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DDX20 | up-regulates
binding
|
FOXL2 | 0.463 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Ovary | |||
| + | FOXL2 | up-regulates
|
Apoptosis | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Ovary | |||