Summary

Name RAP1A
Full Name Ras-related protein Rap-1A
Synonyms C21KG, G-22K, GTP-binding protein smg p21A, Ras-related protein Krev-1 | KREV1
Primary ID P62834
Links - -
Type protein
Relations 6
Function Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation RAP1A 0.08
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RAP1A 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RAP1A 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RAP1A 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding AL/b2 integrin 0.08
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding RAP1A 0.08
Publications: 1 Organism: Homo Sapiens