| + |
GNG12 | up-regulates 
binding
|
PLCE1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152612 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
In the non-canonical wntpathway, frizzled uses galfaq or galfai and gbetagamma dimers to activate phospholipase c (plc), resulting in protein kinase c (pkc) activation and calcium mobilization that regulates the transcription factor nfat, and frizzled also signals through the small gtpases rho and rac to c-jun n-terminal kinase (jnk), which activates the ap1 transcription factor |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLCE1 | up-regulates
chemical modification
|
1,2-diacyl-sn-glycerol |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152771 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
Typically galfas stimulates adenylyl cyclase and increases levels of cyclic amp (camp), whereas galfai inhibits adenylyl cyclase and lowers camp levels, and members of the galfaq family bind to and activate phospholipase c (plc), which cleaves phosphatidylinositol bisphosphate (pip2) into diacylglycerol and inositol triphosphate (ip3). The gbeta subunits and ggamma subunits function as a dimer to activate many molecules, including phospholipases, ion channels and lipid kinases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Oxytocin signaling |
| + |
PLCE1 | up-regulates
guanine nucleotide exchange factor
|
HRAS |
0.56 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-82859 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11022047 |
The presence of a rasgef motif in the n terminus of plcepsilon suggests that plcepsilon can activate ras by acting as an exchange factor by promoting the exchange of gtp for bound gdp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Oxytocin signaling |
| + |
PLCE1 | up-regulates 
|
PRKCA |
0.427 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99307 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12645577 |
TNF-alpha Binds to tnfr1 and activates pc-plc to induce pkc? And c-src activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNAQ | up-regulates
binding
|
PLCE1 |
0.286 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152609 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
Typically galfas stimulates adenylyl cyclase and increases levels of cyclic amp (camp), whereas galfai inhibits adenylyl cyclase and lowers camp levels, and members of the galfaq family bind to and activate phospholipase c (plc), which cleaves phosphatidylinositol bisphosphate (pip2) into diacylglycerol and inositol triphosphate (ip3). The gbeta subunits and ggamma subunits function as a dimer to activate manymolecules, including phospholipases, ion channels and lipid kinases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Oxytocin signaling |
| + |
CXCL1 | up-regulates
binding
|
PLCE1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152591 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
In the non-canonical wnt pathway, frizzled uses galfaq or galfai and gbetagamma dimers to activate phospholipase c (plc), resulting in protein kinase c (pkc) activation and calcium mobilization that regulates the transcription factor nfat, and frizzled also signals through the small gtpases rho and rac to c-jun n-terminal kinase (jnk), which activates the ap1 transcription factor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PLCE1
- 
- 