Summary

Name PLCE1
Full Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
Synonyms Pancreas-enriched phospholipase C, Phosphoinositide phospholipase C-epsilon-1, Phospholipase C-epsilon-1, PLC-epsilon-1 | KIAA1516, PLCE, PPLC
Primary ID Q9P212
Links - -
Type protein
Relations 6
Pathways Oxytocin signaling
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downtream of AVIL to allow ARP2/3 complex assembly (PubMed:29058690).

Viewer

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding PLCE1 0.287
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ up-regulates img/direct-activation.png chemical modification 1,2-diacyl-sn-glycerol 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ up-regulates img/direct-activation.png binding PLCE1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png PRKCA 0.424
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png guanine nucleotide exchange factor HRAS 0.555
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ up-regulates img/direct-activation.png binding PLCE1 0.2
Publications: 1 Organism: Homo Sapiens