| + |
GNB1 | up-regulates 
binding
|
PI3K |
0.505 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252679 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 16537363 |
Gbetagamma subunits released from gi can activate pi3k (phosphoinositide 3-kinase), and can be therefore implicated in smo-dependent activation of akt |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GPSM3 | down-regulates quantity by destabilization 
binding
|
GNB1 |
0.352 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264865 |
|
|
|
|
| pmid |
sentence |
| 22843681 |
GPSM3 was found not only to modulate heterotrimeric G-protein subunit signaling through its two active GoLoco motifs, but also to affect monomeric Gbeta subunit biosynthesis and stability|interactions between GPSM3 and Galphai1 or Gbeta1 (20) was assayed by BRET. |
|
| Publications: |
1 |
| + |
GNB1 | up-regulates 
|
PLCG1 |
0.377 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199129 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
Furthermore, this work suggested that the gbetagamma subunits released upon gi activation activated phospholipase c-gamma (plc-gamma) to produce inositol 3 phosphate (ip3) which would subsequently increase intracellular ca2+ abundance. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GPER1 | up-regulates activity
binding
|
GNB1 |
0.352 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251103 |
|
|
|
|
| pmid |
sentence |
| 10696571 |
GPCRs transduce their signal via G-protein heterotrimers (αβγ) that dissociate in free Gα-subunit protein and Gβγ-subunit protein complexes following ligand stimulation; GNB1 stands for the subunit β, which dissociates from the receptor after the binding of GTP on α-subunit. |
|
| Publications: |
1 |
| + |
GNG2 | up-regulates activity
binding
|
GNB1 |
0.937 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251106 |
|
|
|
|
| pmid |
sentence |
| 10696571 |
GNG2 dissociates from the activated receptor, bound with GNB1 as stable dimer. |
|
| Publications: |
1 |
| + |
GNB1 | up-regulates activity
|
SRC |
0.455 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251107 |
|
|
|
|
| pmid |
sentence |
| 15345719 |
In this study, we investigated the possible role of the Gβγ heterodimer in signaling Gi-induced Src activation |
|
| Publications: |
1 |
| + |
SMO | up-regulates
binding
|
GNB1 |
0.352 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199174 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148537 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16885213 |
Consistent with its predicted topology, smo couples to a specific family of inhibitory g protein (gis) to regulate hh signaling. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
GNB1 | up-regulates activity
binding
|
GNG2 |
0.937 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251105 |
|
|
|
|
| pmid |
sentence |
| 10696571 |
GNB1 dissociates from the receptor, bound with GNG2 as stable dimer |
|
| Publications: |
1 |
| + |
GNB1 | up-regulates
binding
|
PLCB2 |
0.535 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-19447 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1465133 |
Activation of plc-beta 2 by beta gamma subunits may be an important mechanism by which pertussis toxin-sensitive g proteins stimulate plc. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD3 | up-regulates
binding
|
GNB1 |
0.352 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152600 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
In the non-canonical wnt signalling pathway, frizzled uses galphaq or galphai and gbetagamma dimers to activate phospholipase c (plc), resulting in protein kinase c (pkc) activation and calcium mobilization that regulates the transcription factor nfat. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNB1 | down-regulates
binding
|
PLCB1 |
0.458 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-44369 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8870665 |
These results indicate that g-protein beta gamma subunits constitute a mechanism by which g-protein mediate a rapid and transient plc- beta 1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNB1 | up-regulates
binding
|
PIK3CA |
0.541 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-145119 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 16537363 |
Gbetagamma subunits released from gi can activate pi3k (phosphoinositide 3-kinase), and can be therefore implicated in smo-dependent activation of akt |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNB1 | form complex 
binding
|
GNB/GNG |
0.937 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255004 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23994464 |
Instead, our current understanding is that the majority of GPCR signal transduction in neutrophils occurs through the Gβγ subunit |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
GNB1
- 
- 