Summary

Name UBE2I
Full Name SUMO-conjugating enzyme UBC9
Synonyms SUMO-protein ligase, Ubiquitin carrier protein 9, Ubiquitin carrier protein I, Ubiquitin-conjugating enzyme E2 I, Ubiquitin-protein ligase I, p18 | UBC9, UBCE9
Primary ID P63279
Links - -
Type protein
Relations 11
Function Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png sumoylation SMAD4 0.40
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png sumoylation CEBPA
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png sumoylation PLAG1 0.31
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png sumoylation FOXL2 0.23
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination MITF 0.32
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png sumoylation SOX6
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding UBE2I 0.52
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png sumoylation ETV5 0.37
Publications: 1 Organism: Homo Sapiens