| + |
MDK | up-regulates 
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282578 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 21632553 |
MK overexpression contributes to EMT in pancreatic cancer |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIF1A | up-regulates quantity by expression 
transcriptional regulation
|
MDK |
0.454 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282595 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20431264 |
Hypoxia induces MK expression through the binding of hypoxia inducible factor-1α (HIF-1α) to a hypoxia responsive element in the MK promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDK | up-regulates quantity by expression
transcriptional regulation
|
CXCL8 |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282596 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20431265 |
The endothelial cells secrete MK, which acts on smooth muscle cells and induces production of factors including IL8. IL8 then acts on the endothelial cells and promotes their growth. Thus, MK plays a key role in the interaction between epithelial cells and mesenchymal cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDK | up-regulates activity
phosphorylation
|
STAT3 |
0.337 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282594 |
|
|
Mus musculus |
3T3-L1 Cell |
| pmid |
sentence |
| 20431264 |
Phosphorylation of STAT3 by MK stimulates the proliferation of postconfluent 3T3-L1 cells, leading to adipogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CTNNB1 | up-regulates quantity by expression
transcriptional regulation
|
MDK |
0.344 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282597 |
|
|
Homo sapiens |
Glioma Cell |
| pmid |
sentence |
| 26550177 |
Midkine, also known as neurite growth-promoting factor 2 (NEGF2), plays an important role in cell proliferation, apoptosis and differentiation. Recent studies have shown that Midkine is up-regulated in several types of human cancers. In the present study, we found that Wnt3a administration or transfection of a constitutively activated β-catenin promoted Midkine expression in glioma cells. We further identified a TCF/LEF binding site, with which beta-catenin interacts, on the proximal promoter region of Midkine gene, by luciferase reporter and chromatin immunoprecipitation assays. Thus, our results suggest a previously unknown Wnt/β-catenin/Midkine molecular network controlling glioma development.β-catenin binding to the promoter region of Midkine |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
heparin | up-regulates activity
binding
|
MDK |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282602 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20431264 |
Midkine is a heparin-binding cytokine or a growth factor with a molecular weight of 13 kDa. Midkine binds to oversulfated structures in heparan sulfate and chondroitin sulfate. The midkine receptor is a molecular complex containing proteoglycans. Midkine promotes migration, survival and other activities of target cells. Midkine has about 50% sequence identity with pleiotrophin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDK | up-regulates activity
binding
|
NCL |
0.458 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282574 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 41570933 |
While not a classical transmembrane receptor, nucleolin, a multifunctional protein localized to the nucleus and cell membrane in cancer cells, can bind MDK and facilitate its internalization and mitogenic effects. This interaction has been implicated in proliferation and angiogenesis, particularly in HCC and breast cancer |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDK | up-regulates activity
binding
|
LRP1 |
0.454 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282588 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 39349474 |
LRP, as a receptor of MK, is isolated from 13-d-old rat embryo by MK-affinity chromatography with a Kd of 3.5 nM. 60) MK promotes neuron survival through LRP, and this function can be inhibited by a natural antagonist of LRP, Functional experiments demonstrate that estrogen stimulation induces MDK secretion by ovarian fibroblasts, and binding of MDK to LRP1 increases GC cell migration and invasion. (RAP). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Ovary |
| + |
MDK | up-regulates activity
binding
|
SDC3 |
0.464 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282589 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 24659893 |
Syndecan-3 is a high-affinity receptor for MK and an essential component for neurite outgrowths. Therefore, this suggests that as a neurite growth-promoting factor, MK and its receptor syndecan-3 may play an important role in the perineural invasion of pancreatic cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
all-trans-retinoic acid | up-regulates quantity by expression
|
MDK |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282591 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20431264 |
MK expression is induced by retinoic acid, and the promoter region has a functional retinoic acid-responsive element. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAR | up-regulates quantity by expression
transcriptional regulation
|
MDK |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282592 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20431264 |
MK expression is induced by retinoic acid, and the promoter region has a functional retinoic acid-responsive element. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NR3C1 | down-regulates quantity by repression 
transcriptional regulation
|
MDK |
0.257 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282593 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20431264 |
Glucocorticoid suppresses MK expression through its nuclear receptor." |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDK | up-regulates activity
binding
|
CSPG5 |
0.284 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282586 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24694599 |
Both MK and PTN bind to the acidic amino cluster box domain of NGC without being affected by chondroitinase ABC treatment, while MK also binds to the chondroitin sulfate attachment domain, which is sensitive to chondroitinase ABC digestion.5 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDK | up-regulates activity
binding
|
SDC1 |
0.41 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282572 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 41570933 |
Syndecans are transmembrane HSPGs that act as co-receptors for MDK, facilitating clustering with other signaling partners such as LRP1 or integrins. Syndecan-1 is critical for cell–matrix interaction and angiogenesis, and in the TME, the MDK–SDC1 complex enhances fibroblast activation, ECM deposition, and metastatic invasion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDK | down-regulates activity
binding
|
PTPRZ1 |
0.476 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282573 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 41570933 |
PTPζ, also known as RPTPβ/ζ, is a chondroitin sulfate-modified transmembrane phosphatase prominently expressed in the central nervous system and gliomas. MDK binding to PTPζ inhibits its phosphatase activity, leading to hyperphosphorylation of downstream oncogenic proteins (e.g., β-catenin, Fyn), which promotes cell survival and migration. This mechanism is particularly relevant in GBM and neural crest-derived tumors |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDK | up-regulates activity
binding
|
NOTCH2 |
0.514 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282579 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 21632553 |
MK mediates chemoresistance through binding and activation of Notch-2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
gemcitabine | up-regulates quantity by expression
|
MDK |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282580 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 21632553 |
Indeed, we found that MK mRNA expression is dose-dependently induced by gemcitabine in chemoresistant PDAC cells (Fig. 2B, top). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDK | up-regulates activity
binding
|
ALK |
0.468 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282581 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24694599 |
Comparably, MK binds to ALK with an apparent Kd of 170 pM on intact cells transfected with ALK, and the binding of MK can be inhibited by PTN and by monoclonal antibodies against the extracellular ligand-binding domain of ALK. Many kinds of cancer cells and normal cells that expressed ALK have proliferation and survival activity after MK or PTN stimulation,11–13) indicating that ALK is an important functional receptor for MK and PTN |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDK | up-regulates activity
binding
|
A4/b1 integrin |
0.433 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282583 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24694599 |
MK induces migration of osteoblastic cells and neurite outgrowth of embryonic neurons through the α4β1- and α6β1-integrins which can be inhibited by anti-α4 antibody and anti-α6 antibody respectively.53) Unlike MK, PTN interacts with integrin ανβ3, and the binding is cell adhesion motif-RGD independent. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDK | up-regulates activity
binding
|
A6/b1 integrin |
0.435 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282584 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24694599 |
MK induces migration of osteoblastic cells and neurite outgrowth of embryonic neurons through the α4β1- and α6β1-integrins which can be inhibited by anti-α4 antibody and anti-α6 antibody respectively.53) Unlike MK, PTN interacts with integrin ανβ3, and the binding is cell adhesion motif-RGD independent. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MDK | up-regulates
binding
|
NOTCH2 |
0.514 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-161427 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18469519 |
We showed that mk binds to the notch2 receptor in hacat keratinocytes. We further found that mk activates notch2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
MDK
- 
- 