| + |
BIRC3 | up-regulates activity 
ubiquitination, polyubiquitination
|
RIPK1 |
0.741 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179104 |
Lys377 |
NEPSLQSkLQDEANY |
Homo sapiens |
|
| pmid |
sentence |
| 18570872 |
In this report, we show that ciap1 and ciap2 promote cancer cell survival by functioning as e3 ubiquitin ligases that maintain constitutive ubiquitination of the rip1 adaptor protein. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179443 |
Lys377 |
NEPSLQSkLQDEANY |
Homo sapiens |
|
| pmid |
sentence |
| 18621737 |
In this report, we show that ciap1 and ciap2 promote cancer cell survival by functioning as e3 ubiquitin ligases that maintain constitutive ubiquitination of the rip1 adaptor protein. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-145855 |
Lys377 |
NEPSLQSkLQDEANY |
Homo sapiens |
|
| pmid |
sentence |
| 16603398 |
In this report, we show that ciap1 and ciap2 promote cancer cell survival by functioning as e3 ubiquitin ligases that maintain constitutive ubiquitination of the rip1 adaptor protein. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272713 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21931591 |
CIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).Together, our results demonstrate that depleting cIAP1/2 inhibits RIP1-4 mediated NF-kB activation without affecting RIP auto-phosphorylation. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
BIRC3 | down-regulates activity 
ubiquitination
|
BIRC3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-121880 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 14960576 |
Ciap1 and ciap2 undergo autoubiquitination and degradation upon binding to the iap antagonist second mitochondrial activator of caspases (smac)/direct iap-binding protein with low pi (diablo), which is released from the mitochondria. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL1 Signaling |
| + |
BIRC3 | up-regulates activity
binding
|
BIRC2 |
0.482 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199088 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23070005 |
Ligand-stimulated aggregation of receptor complexes causes recruitment of multiple traf2 trimers, which in turn leads to cIAP1 or cIAP2 dimerization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BIRC3 | up-regulates activity
polyubiquitination
|
RIPK4 |
0.359 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272709 |
|
lys145 |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21931591 |
CIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).Together, our results demonstrate that depleting cIAP1/2 inhibits RIP1-4 mediated NF-kB activation without affecting RIP auto-phosphorylation.Lysine residues K51 and K145 of RIP4 are critical for cIAP1-mediated ubiquitination and NF-kB activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272707 |
|
lys51 |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21931591 |
CIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).Together, our results demonstrate that depleting cIAP1/2 inhibits RIP1-4 mediated NF-kB activation without affecting RIP auto-phosphorylation.Lysine residues K51 and K145 of RIP4 are critical for cIAP1-mediated ubiquitination and NF-kB activation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
BIRC3 | down-regulates
binding
|
CASP9 |
0.754 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-56481 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9545235 |
Xiap, birc2 and birc3 were shown to bind pro-casp9. Iaps may suppress casp9 by direct auto-activation of pro-caspase-11 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
XAF1 | down-regulates
binding
|
BIRC3 |
0.396 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-155288 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17613533 |
Immunoprecipitation studies indicate that xaf1 binds to xiap,birc2,birc3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BIRC3 | up-regulates activity
polyubiquitination
|
RIPK2 |
0.783 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272715 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21931591 |
CIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).Together, our results demonstrate that depleting cIAP1/2 inhibits RIP1-4 mediated NF-kB activation without affecting RIP auto-phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PELI1 | up-regulates quantity by stabilization
ubiquitination
|
BIRC3 |
0.462 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259395 |
|
|
Homo sapiens |
NCI-H1299 Cell |
| pmid |
sentence |
| 27248820 |
Notably, Pellino-1 directly interacted with cIAP2 and stabilized cIAP2 through lysine63-mediated polyubiquitination via its E3 ligase activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL1 Signaling |
| + |
TRAF2 | up-regulates
binding
|
BIRC3 |
0.889 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179452 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18621737 |
A traf2 trimer interacts with one ciap2 both in the crystal and in solution through its death domain and amino-terminal region, tradd recruits rip1 (receptor-interacting protein), traf2, and through its interaction with traf2, c-iap1 and c-iap2 (13). Traf2 recruit ciap1 and ciap2. A traf2 trimer interacts with one ciap2 both in the crystal and in solution. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182124 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18997792 |
A traf2 trimer interacts with one ciap2 both in the crystal and in solution through its death domain and amino-terminal region, tradd recruits rip1 (receptor-interacting protein), traf2, and through its interaction with traf2, c-iap1 and c-iap2 (13). Traf2 recruit ciap1 and ciap2. A traf2 trimer interacts with one ciap2 both in the crystal and in solution. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182137 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18997794 |
A traf2 trimer interacts with one ciap2 both in the crystal and in solution through its death domain and amino-terminal region, tradd recruits rip1 (receptor-interacting protein), traf2, and through its interaction with traf2, c-iap1 and c-iap2 (13). Traf2 recruit ciap1 and ciap2. A traf2 trimer interacts with one ciap2 both in the crystal and in solution. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-164785 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20385093 |
A traf2 trimer interacts with one ciap2 both in the crystal and in solution through its death domain and amino-terminal region, tradd recruits rip1 (receptor-interacting protein), traf2, and through its interaction with traf2, c-iap1 and c-iap2 (13). Traf2 recruit ciap1 and ciap2. A traf2 trimer interacts with one ciap2 both in the crystal and in solution. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-39596 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8548810 |
The c-iaps associate with traf1 and traf2 |
|
| Publications: |
5 |
Organism: |
Homo Sapiens |
| Pathways: | IL1 Signaling |
| + |
AT-406 | down-regulates
chemical inhibition
|
BIRC3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-189957 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DIABLO | down-regulates activity
binding
|
BIRC3 |
0.788 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80225 |
|
|
Homo sapiens |
HEK-293 Cell, NTERA-2 Cell |
| pmid |
sentence |
| 10929712 |
Diablo may promote apoptosis by binding to iaps and preventing them from inhibiting caspases. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-80209 |
|
|
Homo sapiens |
HEK-293 Cell, NTERA-2 Cell |
| pmid |
sentence |
| 10929711 |
Smac promotes caspase-9 activation by binding to inhibitor of apoptosis proteins, iaps, and removing their inhibitory activity. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
BIRC3 | down-regulates quantity by destabilization
polyubiquitination
|
PACS2 |
0.288 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272852 |
|
|
in vitro |
|
| pmid |
sentence |
| 24633224 |
Under basal conditions, PACS-2 underwent K48-linked poly-ubiquitination, resulting in PACS-2 proteasomal degradation. Biochemical assays showed cIAP-1 and cIAP-2 interacted with PACS-2 in vitro and co-immunoprecipitation studies demonstrated that the two cIAPs bound PACS-2 in vivo. More importantly, both cIAP-1 and cIAP-2 directly mediated PACS-2 ubiquitination in a cell-free assay. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
BIRC3 | up-regulates activity
polyubiquitination
|
RIPK3 |
0.638 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272714 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21931591 |
CIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).Together, our results demonstrate that depleting cIAP1/2 inhibits RIP1-4 mediated NF-kB activation without affecting RIP auto-phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BIRC3 | down-regulates
ubiquitination
|
MAP3K14 |
0.641 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167298 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20682767 |
Ciap1/2 (cellular inhibitor of apoptosis 1 and 2) ubiquitinate nik for degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BIRC3 | down-regulates quantity by destabilization
polyubiquitination
|
RIPK1 |
0.741 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272637 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 18570872 |
In this report, we show that cIAP1 and cIAP2 promote cancer cell survival by functioning as E3 ubiquitin ligases that maintain constitutive ubiquitination of the RIP1 adaptor protein. We demonstrate that AEG40730, a compound modeled on BIR-binding tetrapeptides, binds to cIAP1 and cIAP2, facilitates their autoubiquitination and proteosomal degradation, and causes a dramatic reduction in RIP1 ubiquitination. We show that cIAP1 and cIAP2 directly ubiquitinate RIP1 and induce constitutive RIP1 ubiquitination in cancer cells and demonstrate that constitutively ubiquitinated RIP1 associates with the prosurvival kinase TAK1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BIRC3 | down-regulates quantity by destabilization
ubiquitination
|
DIABLO |
0.788 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271391 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 12525502 |
Here we show that cIAP1 and cIAP2 are E3 ubiquitin-protein isopeptide ligases (ubiquitin ligases) for Smac. cIAPs stimulate Smac ubiquitination both in vivo and in vitro, leading to Smac degradation. cIAP1 and cIAP2 associate with overlapping but distinct subsets of E2 (ubiquitin carrier protein) ubiquitin-conjugating enzymes. The substrate-dependent E3 activity of cIAPs is mediated by their RING domains and is dependent on the specific interactions between cIAPs and Smac. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NfKb-p65/p50 | up-regulates quantity by expression 
transcriptional regulation
|
BIRC3 |
0.671 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-64103 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9916987 |
The iaps have been shown to be induced by nf-kappab or v-rel in multiple cell lines and conversely, hiap1 and hiap2 have been shown to activate nf-kappab possibly forming a positive feed-back loop. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL1 Signaling |
| + |
DIABLO | down-regulates quantity
binding
|
BIRC3 |
0.788 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-121886 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14960576 |
Smac/diablo selectively causes the rapid degradation of c-iap1 and c-iap2 in hela cells. Smac binding to c-iap via its n-terminal iap-binding motif is the prerequisite for this effect |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZNF804A | down-regulates quantity by repression
transcriptional regulation
|
BIRC3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269467 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23434502 |
ZNF804A has been implicated in susceptibility to schizophrenia by several genome-wide association studies (GWAS), follow-up association studies and meta-analyses. ZNF804A was identified as a schizophrenia-associated gene by GWAS and was predicted to play a role in DNA binding and transcription To identify the genes that are affected by ZNF804A, we manipulated the expression of the ZNF804A protein in HEK293 human embryonic kidney cell lines and performed a cDNA microarray analysis followed by qPCR. We found that ZNF804A-overexpression up-regulated four genes (ANKRD1, INHBE, PIK3AP1, and DDIT3) and down-regulated three genes (CLIC2, MGAM, and BIRC3). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFKB1 | up-regulates quantity by expression
transcriptional regulation
|
BIRC3 |
0.64 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-59951 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9733516 |
Thus, our data indicate that nf-kb controls the expression of traf1 and traf2 and c-iap1 and c-iap2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Ub:E2 | up-regulates activity
ubiquitination
|
BIRC3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271049 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BIRC3 | down-regulates quantity by destabilization
ubiquitination
|
TRAF2 |
0.889 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182131 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18997794 |
Traf3-binding receptors stabilize nik by activating ciap-dependent degradation of traf2 and traf3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL1 Signaling |
3.0
BIRC3
- 
- 