Summary

Name BIRC3
Full Name Baculoviral IAP repeat-containing protein 3
Synonyms Apoptosis inhibitor 2, API2, Cellular inhibitor of apoptosis 2, C-IAP2, IAP homolog C, Inhibitor of apoptosis protein 1, hIAP-1, hIAP1, RING finger protein 49, TNFR2-TRAF-signaling complex protein 1 | API2, MIHC, RNF49
Primary ID Q13489
Links - -
Type protein
Relations 31
Pathways IL1 Signaling
Inhibitors AT-406
Function Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png ubiquitination, polyubiquitination RIPK1 0.737
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png polyubiquitination RIPK2 0.78
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination BIRC3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding BIRC2 0.468
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation BIRC3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding BIRC3 0.784
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination TRAF2 0.886
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling
+ down-regulates img/direct_inhibition.png ubiquitination MAP3K14 0.632
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BIRC3 0.652
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding BIRC3 0.402
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CASP9 0.749
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BIRC3 0.674
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling
+ up-regulates img/direct-activation.png binding BIRC3 0.886
Publications: 5 Organism: Homo Sapiens
Pathways:IL1 Signaling
+ up-regulates activity img/direct-activation.png polyubiquitination RIPK4 0.362
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination BIRC3 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling
+ up-regulates quantity by stabilization img/direct-activation.png ubiquitination BIRC3 0.47
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling
+ down-regulates quantity img/direct_inhibition.png binding BIRC3 0.784
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination RIPK1 0.737
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png polyubiquitination RIPK3 0.63
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination PACS2 0.289
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition BIRC3 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination DIABLO 0.784
Publications: 1 Organism: Homo Sapiens