Summary

Name AMER1
Full Name APC membrane recruitment protein 1
Synonyms Amer1, Protein FAM123B, Wilms tumor gene on the X chromosome protein | FAM123B, WTX
Primary ID Q5JTC6
Links - -
Type protein
Relations 8
Function Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png relocalization AXIN1 0.32
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization GSK3B 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding WT1 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP6 0.32
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CTNNB1 0.33
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CSNK1G1 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization GSK3B/Axin/APC 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization APC 0.33
Publications: 1 Organism: Homo Sapiens