4.0
Summary
| Name |  TAOK1View Modifications |
| Full Name | Serine/threonine-protein kinase TAO1 |
| Synonyms | Kinase from chicken homolog B, hKFC-B, MARK Kinase, MARKK, Prostate-derived sterile 20-like kinase 2, PSK-2, PSK2, Prostate-derived STE20-like kinase 2, Thousand and one amino acid protein kinase 1, TAOK1, hTAOK1 | KIAA1361, MAP3K16, MARKK |
| Primary ID | Q7L7X3 |
| Links |  -  -  |
| Type | protein |
| Relations | 12 |
| Pathways | P38 Signaling |
| Function | Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | TAOK1 | up-regulates activity 
phosphorylation
|
MAP2K3 | 0.579 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | P38 Signaling | |||
| + | ATM | up-regulates
phosphorylation
|
TAOK1 | 0.422 |
| Publications: | 4 | Organism: | Homo Sapiens | |
| + | TAOK1 | up-regulates activity
phosphorylation
|
MARK2 | 0.413 |
| Publications: | 1 | Organism: | In Vitro | |
| + | DNA_damage | up-regulates 
|
TAOK1 | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | P38 Signaling | |||
| + | TAOK1 | up-regulates
phosphorylation
|
STK3 | 0.297 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TAOK1 | up-regulates
phosphorylation
|
STK4 | 0.366 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | STK24 | up-regulates activity
phosphorylation
|
TAOK1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GNAO1 | up-regulates
|
TAOK1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TAOK1 | up-regulates
phosphorylation
|
STK3/4 | 0.369 |
| Publications: | 1 | Organism: | Homo Sapiens | |