Summary

Name MAML1
Full Name Mastermind-like protein 1
Synonyms Mam-1 | KIAA0200
Primary ID Q92585
Links - -
Type protein
Relations 22
Function Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.

Viewer

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding, relocalization CDK8 0.577
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation MAML1 0.632
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.919
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization CCNC 0.419
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH2 0.798
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding, relocalization EP300 0.632
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH3 0.779
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TP53 0.318
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates activity img/direct_inhibition.png acetylation H4C1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CTNNB1 0.282
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates activity img/direct_inhibition.png acetylation H3C1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH 0.919
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RBPJ 0.868
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOTCH1 0.919
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH4 0.696
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization CCNT1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAML1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png acetylation Histone H3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MEF2C 0.409
Publications: 1 Organism: Homo Sapiens