| + |
SRC | up-regulates activity 
phosphorylation
|
CNKSR1 |
0.527 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275919 |
Tyr26 |
LDDSLQDyPFEDWQL |
|
|
| pmid |
sentence |
| 26319181 |
We identified Tyr 26 as a PDGF-induced and, additionally, Tyr 519 and Tyr 665 as SRC-induced tyrosine phosphorylation sites. Phosphomimetic mutants indicate that phosphorylation of Tyr 519 recruits CNK1 to the nucleus and additional phosphorylation of Tyr 26 enables CNK1 to promote SRE-dependent gene expression. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275918 |
Tyr519 |
PPREEDCySETEAED |
|
|
| pmid |
sentence |
| 26319181 |
We identified Tyr 26 as a PDGF-induced and, additionally, Tyr 519 and Tyr 665 as SRC-induced tyrosine phosphorylation sites. Phosphomimetic mutants indicate that phosphorylation of Tyr 519 recruits CNK1 to the nucleus and additional phosphorylation of Tyr 26 enables CNK1 to promote SRE-dependent gene expression. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275920 |
Tyr665 |
KEQNRELySEGLGAW |
|
|
| pmid |
sentence |
| 26319181 |
We identified Tyr 26 as a PDGF-induced and, additionally, Tyr 519 and Tyr 665 as SRC-induced tyrosine phosphorylation sites. Phosphomimetic mutants indicate that phosphorylation of Tyr 519 recruits CNK1 to the nucleus and additional phosphorylation of Tyr 26 enables CNK1 to promote SRE-dependent gene expression. |
|
| Publications: |
3 |
| + |
CNKSR1 | up-regulates quantity by stabilization
binding
|
MAP4K4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282682 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40010432 |
In this study, we characterized the interaction mechanisms between MAP4K kinases (MAP4K4, MINK1 and TNIK) and the CNKSR1/2/3 scaffold proteins, and discovered that SAMD12, a familial adult myoclonic epilepsy disease gene product, or its close homolog SAMD10, binds to CNKSR1/2/3 with exceptionally strong affinities and can quantitatively displace MAP4K from CNKSR1/2/3 scaffolds. The CNK family proteins are evolutionarily conserved scaffold proteins. Three CNK paralogs, CNKSR1, CNKSR2 and CNKSR3, are expressed in mammals.The CNKSR family proteins interact with SAMDs and MAP4Ks. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Neuron |
| + |
SAMD10 | down-regulates quantity by destabilization 
binding
|
CNKSR1 |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282687 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40010432 |
In this study, we characterized the interaction mechanisms between MAP4K kinases (MAP4K4, MINK1 and TNIK) and the CNKSR1/2/3 scaffold proteins, and discovered that SAMD12, a familial adult myoclonic epilepsy disease gene product, or its close homolog SAMD10, binds to CNKSR1/2/3 with exceptionally strong affinities and can quantitatively displace MAP4K from CNKSR1/2/3 scaffolds. The CNK family proteins are evolutionarily conserved scaffold proteins. Three CNK paralogs, CNKSR1, CNKSR2 and CNKSR3, are expressed in mammals.The CNKSR family proteins interact with SAMDs and MAP4Ks. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Neuron |
| + |
CNKSR1 | up-regulates
binding
|
RAF1 |
0.722 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135674 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15845549 |
Here we demonstrate that the connector enhancer of ksr1, cnk1, mediates src-dependent tyrosine phosphorylation and activation of raf-1. Cnk1 binds preactivated raf-1 and activated src and forms a trimeric complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CNKSR1 | up-regulates
binding
|
RASSF1 |
0.395 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198432 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22830020 |
Cnk1 binds to rassf1a and promotes apoptosis through a pathway that requires rassf1a and mst kinases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CNKSR1 | up-regulates quantity by stabilization
binding
|
MINK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282679 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40010432 |
In this study, we characterized the interaction mechanisms between MAP4K kinases (MAP4K4, MINK1 and TNIK) and the CNKSR1/2/3 scaffold proteins, and discovered that SAMD12, a familial adult myoclonic epilepsy disease gene product, or its close homolog SAMD10, binds to CNKSR1/2/3 with exceptionally strong affinities and can quantitatively displace MAP4K from CNKSR1/2/3 scaffolds. The CNK family proteins are evolutionarily conserved scaffold proteins. Three CNK paralogs, CNKSR1, CNKSR2 and CNKSR3, are expressed in mammals.The CNKSR family proteins interact with SAMDs and MAP4Ks. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Neuron |
| + |
SAMD12 | down-regulates quantity by destabilization
binding
|
CNKSR1 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282685 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40010432 |
In this study, we characterized the interaction mechanisms between MAP4K kinases (MAP4K4, MINK1 and TNIK) and the CNKSR1/2/3 scaffold proteins, and discovered that SAMD12, a familial adult myoclonic epilepsy disease gene product, or its close homolog SAMD10, binds to CNKSR1/2/3 with exceptionally strong affinities and can quantitatively displace MAP4K from CNKSR1/2/3 scaffolds. The CNK family proteins are evolutionarily conserved scaffold proteins. Three CNK paralogs, CNKSR1, CNKSR2 and CNKSR3, are expressed in mammals.The CNKSR family proteins interact with SAMDs and MAP4Ks. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Neuron |
| + |
CNKSR1 | up-regulates activity
binding
|
EPHB1 |
0.289 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275921 |
|
|
|
|
| pmid |
sentence |
| 26319181 |
The phosphorylated CNK1 interacts with ephrinB1. The binding of ephrinB1 to CNK1 connects RhoA and p115RhoGEF with ephrinB1-associated MKK4, promoting JNK activation and cell migration. |
|
| Publications: |
1 |
| + |
CNKSR1 | up-regulates quantity by stabilization
binding
|
TNIK |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-282677 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 40010432 |
In this study, we characterized the interaction mechanisms between MAP4K kinases (MAP4K4, MINK1 and TNIK) and the CNKSR1/2/3 scaffold proteins, and discovered that SAMD12, a familial adult myoclonic epilepsy disease gene product, or its close homolog SAMD10, binds to CNKSR1/2/3 with exceptionally strong affinities and can quantitatively displace MAP4K from CNKSR1/2/3 scaffolds. The CNK family proteins are evolutionarily conserved scaffold proteins. Three CNK paralogs, CNKSR1, CNKSR2 and CNKSR3, are expressed in mammals.The CNKSR family proteins interact with SAMDs and MAP4Ks. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Neuron |
4.0
CNKSR1
- 
- 