4.0
Summary
| Name |  RHEBView Modifications |
| Full Name | GTP-binding protein Rheb |
| Synonyms | Ras homolog enriched in brain | RHEB2 |
| Primary ID | Q15382 |
| Links |  -  -  |
| Type | protein |
| Relations | 13 |
| Pathways | AMPK Signaling, Insulin Signaling, Luminal Breast Cancer, mTOR in cancer, Mitochondrial dynamics in T cell exhaustion, MTOR Signaling, YAP/TAZ regulation |
| Function | Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAPKAPK5 | down-regulates activity 
phosphorylation
|
RHEB | 0.403 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TSC2 | down-regulates activity
gtpase-activating protein
|
RHEB | 0.922 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Brain | |||
| + | RHEB | up-regulates activity 
binding
|
MTOR | 0.95 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Pathways: | MTOR Signaling | |||
| + | RHEB | down-regulates activity
gtpase-activating protein
|
FKBP8 | 0.535 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RHEB | down-regulates
binding
|
FKBP8 | 0.535 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BNIP3 | down-regulates
binding
|
RHEB | 0.753 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RHEB | up-regulates
binding
|
PLD1 | 0.537 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TSC1 | down-regulates activity
binding
|
RHEB | 0.912 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Insulin Signaling | |||
| + | TSC | down-regulates activity
gtpase-activating protein
|
RHEB | 0.917 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | AMPK Signaling, Insulin Signaling, Luminal Breast Cancer, mTOR in cancer, MTOR Signaling | |||
| + | RHEB | down-regulates activity
binding
|
EIF2AK3 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | RHEB | up-regulates activity
|
mTORC1 | 0.8 |
| Publications: | 2 | Organism: | Mus Musculus, Homo Sapiens | |
| Pathways: | AMPK Signaling, Insulin Signaling, Luminal Breast Cancer, mTOR in cancer | |||