| + |
GNG12 | up-regulates 
binding
|
PI3K |
0.373 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252681 |
|
|
Homo sapiens |
Colonic Cancer Cell |
| pmid |
sentence |
| 16293724 |
We show that pge2 stimulates colon cancer cell growth through its heterotrimeric guanine nucleotide-binding protein (g protein)coupled receptor, ep2, by a signaling route that involves the activation of phosphoinositide 3-kinase and the protein kinase akt by free g protein bg subunits and the direct association of the g protein as subunit with the regulator of g protein signaling (rgs) domain of axin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNG12 | down-regulates 
binding
|
PRKACA |
0.385 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152615 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
As pka suppresses the activity of gli, smo might use the stimulation of pi3k by galfai and gbetagamma subu- nits to block pka in cells that have high levels of camp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNG12 | up-regulates
binding
|
AKT2 |
0.386 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141792 |
|
|
Homo sapiens |
Colonic Cancer Cell |
| pmid |
sentence |
| 16293724 |
We show that pge2 stimulates colon cancer cell growth through its heterotrimeric guanine nucleotide-binding protein (g protein) coupled receptor, ep2, by a signaling route that involves the activation of phosphoinositide 3-kinase and the protein kinase akt by free g protein bg subunits and the direct association of the g protein as subunit with the regulator of g protein signaling (rgs) domain of axin. This leads to the inactivation and release of glycogen synthase kinase 3b from its complex with axin, thereby relieving the inhibitory phosphorylation of b-catenin and activating its signaling pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AGTR1 | up-regulates
binding
|
GNG12 |
0.408 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-171763 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21289285 |
These results indicate that ang ii increases endothelial arginase activity/expression through galfa12/13 g proteins coupled to at(1) receptors and subsequent activation of rhoa/rock/p38 mapk pathways leading to endothelial dysfunction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTGER3 | up-regulates
binding
|
GNG12 |
0.426 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-88195 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 12038972 |
Ep3 receptor signals are primarily involved in adenylyl cyclase via g(i) activation, and in ca(2+)-mobilization through g(beta)(gamma) from g(i) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMO | up-regulates
binding
|
GNG12 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152817 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
As pka suppresses the activity of gli, smo might use the stimulation of pi3k by galfai and gbetagamma subu- nits to block pka in cells that have high levels of camp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNG12 | up-regulates
binding
|
PLCE1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152612 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
In the non-canonical wntpathway, frizzled uses galfaq or galfai and gbetagamma dimers to activate phospholipase c (plc), resulting in protein kinase c (pkc) activation and calcium mobilization that regulates the transcription factor nfat, and frizzled also signals through the small gtpases rho and rac to c-jun n-terminal kinase (jnk), which activates the ap1 transcription factor |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNG12 | up-regulates
binding
|
PIK3CA |
0.373 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141795 |
|
|
Homo sapiens |
Colonic Cancer Cell |
| pmid |
sentence |
| 16293724 |
We show that pge2 stimulates colon cancer cell growth through its heterotrimeric guanine nucleotide-binding protein (g protein)coupled receptor, ep2, by a signaling route that involves the activation of phosphoinositide 3-kinase and the protein kinase akt by free g protein bg subunits and the direct association of the g protein as subunit with the regulator of g protein signaling (rgs) domain of axin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
prostaglandin E2 | up-regulates
chemical activation
|
GNG12 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141820 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16293724 |
Although pge2 promotes nucleotide exchange on gas and subsequent dissociation of gtp-bound gas from gbg subunits. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
GNG12
- 
- 