Relation Results

Summary

Name GNG12
Full Name Guanine nucleotide-binding protein G
Synonyms GBG12_HUMAN
Primary ID Q9UBI6
Links - -
Type protein
Relations 9
Function Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and ga ...
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Type: Score: Layout: SPV 
0.3970.20.3840.3910.3840.80.20.4180.435GNG12AKT2SMOPI3KPRKACAPIK3CAprostaglandin E2PLCE1AGTR1PTGER3

Relations

Regulator
Mechanism
target
score
+ up-regulates img/direct-activation.png binding AKT2 0.397
Identifier Residue Sequence Organism Cell Line
SIGNOR-141792 Homo sapiens Colonic Cancer Cell
pmid sentence
We show that pge2 stimulates colon cancer cell growth through its heterotrimeric guanine nucleotide-binding protein (g protein) coupled receptor, ep2, by a signaling route that involves the activation of phosphoinositide 3-kinase and the protein kinase akt by free g protein bg subunits and the direct association of the g protein as subunit with the regulator of g protein signaling (rgs) domain of axin. This leads to the inactivation and release of glycogen synthase kinase 3b from its complex with axin, thereby relieving the inhibitory phosphorylation of b-catenin and activating its signaling pathway.
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNG12 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-152817 Homo sapiens
pmid sentence
As pka suppresses the activity of gli, smo might use the stimulation of pi3k by galfai and gbetagamma subu- nits to block pka in cells that have high levels of camp.
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PI3K 0.384
Identifier Residue Sequence Organism Cell Line
SIGNOR-252681 Homo sapiens Colonic Cancer Cell
pmid sentence
We show that pge2 stimulates colon cancer cell growth through its heterotrimeric guanine nucleotide-binding protein (g protein)coupled receptor, ep2, by a signaling route that involves the activation of phosphoinositide 3-kinase and the protein kinase akt by free g protein bg subunits and the direct association of the g protein as subunit with the regulator of g protein signaling (rgs) domain of axin.
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding PRKACA 0.391
Identifier Residue Sequence Organism Cell Line
SIGNOR-152615 Homo sapiens
pmid sentence
As pka suppresses the activity of gli, smo might use the stimulation of pi3k by galfai and gbetagamma subu- nits to block pka in cells that have high levels of camp.
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3CA 0.384
Identifier Residue Sequence Organism Cell Line
SIGNOR-141795 Homo sapiens Colonic Cancer Cell
pmid sentence
We show that pge2 stimulates colon cancer cell growth through its heterotrimeric guanine nucleotide-binding protein (g protein)coupled receptor, ep2, by a signaling route that involves the activation of phosphoinositide 3-kinase and the protein kinase akt by free g protein bg subunits and the direct association of the g protein as subunit with the regulator of g protein signaling (rgs) domain of axin.
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation GNG12 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-141820 Homo sapiens
pmid sentence
Although pge2 promotes nucleotide exchange on gas and subsequent dissociation of gtp-bound gas from gbg subunits.
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PLCE1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-152612 Homo sapiens
pmid sentence
In the non-canonical wntpathway, frizzled uses galfaq or galfai and gbetagamma dimers to activate phospholipase c (plc), resulting in protein kinase c (pkc) activation and calcium mobilization that regulates the transcription factor nfat, and frizzled also signals through the small gtpases rho and rac to c-jun n-terminal kinase (jnk), which activates the ap1 transcription factor
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNG12 0.418
Identifier Residue Sequence Organism Cell Line
SIGNOR-171763 Homo sapiens
pmid sentence
These results indicate that ang ii increases endothelial arginase activity/expression through galfa12/13 g proteins coupled to at(1) receptors and subsequent activation of rhoa/rock/p38 mapk pathways leading to endothelial dysfunction.
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GNG12 0.435
Identifier Residue Sequence Organism Cell Line
SIGNOR-88195 Homo sapiens Neuron
pmid sentence
Ep3 receptor signals are primarily involved in adenylyl cyclase via g(i) activation, and in ca(2+)-mobilization through g(beta)(gamma) from g(i)
Publications: 1 Organism: Homo Sapiens
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