Relation Results

Summary

Name FZD5
Full Name Frizzled-5
Synonyms Fz-5, hFz5, FzE5 | C2orf31
Primary ID Q13467
Links - -
Type protein
Relations 12
Function Receptor for Wnt proteins (PubMed:9054360, PubMed:10097073, PubMed:20530549). Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the ...
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Type: Score: Layout: SPV 
0.6150.8310.40.5090.20.6370.6670.20.7350.6560.5820.701WNT10BFZD5WNT5Ahsa-miR-124-5pZNRF3CEBPADVL3LRP5PPARGLRP6DVL1BAMBIDVL2

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Relations
Regulator
Mechanism
target
score ℹ
+ WNT10Bup-regulates img/direct-activation.png binding FZD5 0.615
Identifier Residue Sequence Organism Cell Line
SIGNOR-210164 Homo sapiens
pmid sentence
Inhibition of adipogenesis by wnt10b is likely mediated by‚ wnt‚ receptors, frizzled 1, 2, and/or 5, and co-receptors low density lipoprotein receptor-related proteins 5 and 8
Publications: 1 Organism: Homo Sapiens
+ WNT5Aup-regulates img/direct-activation.png binding FZD5 0.831
Identifier Residue Sequence Organism Cell Line
SIGNOR-46897 Homo sapiens
pmid sentence
These results identify hfz5 as a receptor for wnt-5a.
Publications: 1 Organism: Homo Sapiens
+ hsa-miR-124-5pdown-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation FZD5 0.4
Identifier Residue Sequence Organism Cell Line
SIGNOR-277969 Homo sapiens Caki-2 Cell
pmid sentence
The current study showed that miR-124 was downregulated in vinblastine- and doxorubicin-resistant renal cancer cells, accompanied by increased levels of FZD5 and P-gp. | Meanwhile, miR-124 targeted FZD5 and abolished its presentation
Publications: 1 Organism: Homo Sapiens
+ ZNRF3down-regulates quantity img/direct_inhibition.png ubiquitination FZD5 0.509
Identifier Residue Sequence Organism Cell Line
SIGNOR-260118 Homo sapiens HEK-293 Cell
pmid sentence
Here we show that the cell-surface transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) and its homologue ring finger 43 (RNF43) are negative feedback regulators of Wnt signalling. ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6.
Publications: 1 Organism: Homo Sapiens
+ FZD5down-regulates img/indirect_inhibition.png CEBPA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-80607 Homo sapiens
pmid sentence
Wnt signaling maintains preadipocytes in an undifferentiated state through inhibition of the adipogenic transcription factors ccaat/enhancer binding protein alpha (c/ebpalpha) and peroxisome proliferator- activated receptor gamma (ppargamma)
Publications: 1 Organism: Homo Sapiens
+ FZD5up-regulates activity img/direct-activation.png binding DVL3 0.637
Identifier Residue Sequence Organism Cell Line
SIGNOR-258963 Homo sapiens
pmid sentence
Upon ligand binding, DVL proteins are recruited to Frizzled receptors at the plasma membrane and co-recruit cytoplasmic transducers, such as Axin, CK1 and GSK3 binding protein (GBP), presumably along with their partners, to promote ?-catenin-dependent signalling. 
Publications: 1 Organism: Homo Sapiens
+ FZD5up-regulates activity img/direct-activation.png binding LRP5 0.667
Identifier Residue Sequence Organism Cell Line
SIGNOR-258969 Homo sapiens
pmid sentence
Here we report that Wnt receptor Frizzled (Frz) and theco-receptors LRP5 and LRP6 (LRP5/6) directly interact with each other and this interaction is regulated by the LRP6 ectodomain.
Publications: 1 Organism: Homo Sapiens
+ FZD5down-regulates img/indirect_inhibition.png PPARG 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-80610 Homo sapiens
pmid sentence
Wnt signaling maintains preadipocytes in an undifferentiated state through inhibition of the adipogenic transcription factors ccaat/enhancer binding protein alpha (c/ebpalpha) and peroxisome proliferator- activated receptor gamma (ppargamma)
Publications: 1 Organism: Homo Sapiens
+ FZD5up-regulates activity img/direct-activation.png binding LRP6 0.735
Identifier Residue Sequence Organism Cell Line
SIGNOR-258966 Homo sapiens
pmid sentence
Here we show that both Fz and Dvl functions are critical for Wnt-induced Lrp6 phosphorylation through Fz-Lrp6 interaction.
Publications: 1 Organism: Homo Sapiens
+ FZD5up-regulates activity img/direct-activation.png binding DVL1 0.656
Identifier Residue Sequence Organism Cell Line
SIGNOR-258957 Homo sapiens
pmid sentence
Upon ligand binding, DVL proteins are recruited to Frizzled receptors at the plasma membrane and co-recruit cytoplasmic transducers, such as Axin, CK1 and GSK3 binding protein (GBP), presumably along with their partners, to promote ?-catenin-dependent signalling. 
Publications: 1 Organism: Homo Sapiens
+ BAMBIup-regulates img/direct-activation.png binding FZD5 0.582
Identifier Residue Sequence Organism Cell Line
SIGNOR-23040 Homo sapiens
pmid sentence
These data together suggest that bambi may form a ternary coreceptor complex with fzd5 and lrp6
Publications: 1 Organism: Homo Sapiens
Tissue: Lung
+ FZD5up-regulates activity img/direct-activation.png binding DVL2 0.701
Identifier Residue Sequence Organism Cell Line
SIGNOR-258960 Homo sapiens
pmid sentence
Upon ligand binding, DVL proteins are recruited to Frizzled receptors at the plasma membrane and co-recruit cytoplasmic transducers, such as Axin, CK1 and GSK3 binding protein (GBP), presumably along with their partners, to promote ?-catenin-dependent signalling. 
Publications: 1 Organism: Homo Sapiens
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