Summary

Name MAPK8IP1
Full Name C-Jun-amino-terminal kinase-interacting protein 1
Synonyms JIP-1, JNK-interacting protein 1, Islet-brain 1, IB-1, JNK MAP kinase scaffold protein 1, Mitogen-activated protein kinase 8-interacting protein 1 | IB1, JIP1, PRKM8IP
Primary ID Q9UQF2
Links - -
Type protein
Relations 22
Pathways SAPK/JNK Signaling
Function The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation MAPK8IP1 0.35
Publications: 5 Organism: Chlorocebus Aethiops
Pathways:SAPK/JNK Signaling
+ up-regulates activity img/direct-activation.png phosphorylation MAPK8IP1 0.53
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK8IP1
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:SAPK/JNK Signaling
+ down-regulates img/direct_inhibition.png binding MAPK8 0.35
Publications: 4 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ down-regulates img/direct_inhibition.png binding RBPJ 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAPK8IP1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ down-regulates img/direct_inhibition.png binding MAP3K12 0.57
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAPK8IP1
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NOTCH1 0.07
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAP3K10 0.37
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAP2K7 0.83
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAPK8IP1 1.00
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png unknown MAPK8IP1 0.25
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MAPK9 0.53
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MAP4K2 0.16
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling