| + |
Met-tRNA(Met) | form complex 
binding
|
Ternary_GTP_eIF2_tRNA_complex |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269117 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32955564 |
In eukaryotes, translation initiation generally occurs by a cap-dependent scanning mechanism, wherein the small (40S) subunit of the ribosome recruits methionyl initiator tRNA (Met-tRNAi) in a ternary complex (TC) with GTP-bound eukaryotic initiation factor 2 (eIF2), in a reaction stimulated by factors eIF1, eIF1A and eIF3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Initiation of Translation |
| + |
EIF1AY | up-regulates activity 
relocalization
|
Ternary_GTP_eIF2_tRNA_complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269148 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12514125 |
Translation initiation factor 1A (eIF1A) is predicted to bind in the decoding site of the 40S ribosome and has been implicated in recruitment of the eIF2-GTP-Met-tRNA i Met ternary complex (TC) and ribosomal scanning. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EIF2B1 | up-regulates activity
guanine nucleotide exchange factor
|
Ternary_GTP_eIF2_tRNA_complex |
0.758 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269139 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15054402 |
EIF2B converts the protein synthesis initiation factor 2 (eIF2) from an inactive GDP-bound form to an active eIF2-GTP complex owing to its guanine nucleotide exchange factor (GEF) activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Initiation of Translation |
| + |
EIF2B4 | up-regulates activity
guanine nucleotide exchange factor
|
Ternary_GTP_eIF2_tRNA_complex |
0.765 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269142 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15054402 |
EIF2B converts the protein synthesis initiation factor 2 (eIF2) from an inactive GDP-bound form to an active eIF2-GTP complex owing to its guanine nucleotide exchange factor (GEF) activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EIF2S3 | form complex
binding
|
Ternary_GTP_eIF2_tRNA_complex |
0.938 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269116 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32955564 |
In eukaryotes, translation initiation generally occurs by a cap-dependent scanning mechanism, wherein the small (40S) subunit of the ribosome recruits methionyl initiator tRNA (Met-tRNAi) in a ternary complex (TC) with GTP-bound eukaryotic initiation factor 2 (eIF2), in a reaction stimulated by factors eIF1, eIF1A and eIF3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EIF2S1 | form complex
binding
|
Ternary_GTP_eIF2_tRNA_complex |
0.944 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269114 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32955564 |
In eukaryotes, translation initiation generally occurs by a cap-dependent scanning mechanism, wherein the small (40S) subunit of the ribosome recruits methionyl initiator tRNA (Met-tRNAi) in a ternary complex (TC) with GTP-bound eukaryotic initiation factor 2 (eIF2), in a reaction stimulated by factors eIF1, eIF1A and eIF3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Initiation of Translation |
| + |
EIF2B2 | up-regulates activity
guanine nucleotide exchange factor
|
Ternary_GTP_eIF2_tRNA_complex |
0.739 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269140 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15054402 |
EIF2B converts the protein synthesis initiation factor 2 (eIF2) from an inactive GDP-bound form to an active eIF2-GTP complex owing to its guanine nucleotide exchange factor (GEF) activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EIF3_complex | up-regulates activity
stabilization
|
Ternary_GTP_eIF2_tRNA_complex |
0.621 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269154 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17581632 |
EIF3 plays many functions in initiation complex formation. It interacts with eIF1, eIF5, eIF4B and eIF4G, and the direct interaction between eIF3 and eIF4G may serve as a bridge between the 40S ribosomal subunit and eIF4F-bound mRNA (Hershey and Merrick, 2000). eIF3 stabilizes the binding of the eIF2-GTP-Met-tRNAiMet ternary complex to the 40S subunit |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Initiation of Translation |
| + |
GTP | form complex
binding
|
Ternary_GTP_eIF2_tRNA_complex |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269118 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32955564 |
In eukaryotes, translation initiation generally occurs by a cap-dependent scanning mechanism, wherein the small (40S) subunit of the ribosome recruits methionyl initiator tRNA (Met-tRNAi) in a ternary complex (TC) with GTP-bound eukaryotic initiation factor 2 (eIF2), in a reaction stimulated by factors eIF1, eIF1A and eIF3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Initiation of Translation |
| + |
EIF2S2 | form complex
binding
|
Ternary_GTP_eIF2_tRNA_complex |
0.954 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269115 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32955564 |
In eukaryotes, translation initiation generally occurs by a cap-dependent scanning mechanism, wherein the small (40S) subunit of the ribosome recruits methionyl initiator tRNA (Met-tRNAi) in a ternary complex (TC) with GTP-bound eukaryotic initiation factor 2 (eIF2), in a reaction stimulated by factors eIF1, eIF1A and eIF3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EIF2B5 | up-regulates activity
guanine nucleotide exchange factor
|
Ternary_GTP_eIF2_tRNA_complex |
0.81 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269138 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15054402 |
EIF2B converts the protein synthesis initiation factor 2 (eIF2) from an inactive GDP-bound form to an active eIF2-GTP complex owing to its guanine nucleotide exchange factor (GEF) activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EIF1AX | up-regulates activity
relocalization
|
Ternary_GTP_eIF2_tRNA_complex |
0.712 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269147 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12514125 |
Translation initiation factor 1A (eIF1A) is predicted to bind in the decoding site of the 40S ribosome and has been implicated in recruitment of the eIF2-GTP-Met-tRNA i Met ternary complex (TC) and ribosomal scanning. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EIF2B3 | up-regulates activity
guanine nucleotide exchange factor
|
Ternary_GTP_eIF2_tRNA_complex |
0.797 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269141 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15054402 |
EIF2B converts the protein synthesis initiation factor 2 (eIF2) from an inactive GDP-bound form to an active eIF2-GTP complex owing to its guanine nucleotide exchange factor (GEF) activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Ternary_GTP_eIF2_tRNA_complex | form complex
binding
|
43S_pre_initiation_complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269159 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35489072 |
In eukaryotes, mRNA is recruited to the 43S pre-initiation complex (43S PIC), which consists of the 40S ribosomal subunit, translation initiation factors eIF1, eIF1A, eIF3, eIF5, and a ternary complex (TC) composed of eIF2, GTP and Met-tRNAiMet. 43S PIC binds to the 5′ end of the mRNA and scans along the 5′ untranslated region (5′UTR) in the 3′ direction to find the start codon (AUG) within the context of an optimal Kozak sequence. Start codon recognition stabilizes the 48S initiation complex (48S IC), initiates dissociation of eIF1, eIF1A, eIF2 and eIF5, and promotes recruitment of the 60S ribosomal subunit to form 80S IC ready to enter the elongation cycle of protein synthesis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Initiation of Translation |
3.0
Ternary_GTP_eIF2_tRNA_complex
CPX-2716