4.0
Summary
| Name |  AML1-ETO
|
| Primary ID | SIGNOR-FP1 |
| Type | Fusion Protein |
| Formed by | Q01196, Q06455 |
| Description | In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of the RUNX1T1(ETO) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.[7] |
| Sequence | MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRTEKHSTMPDSPVDVKTQSRLTPPTMPPPPTTQGAPRTSSFTPTTLTNGTSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGARQLSKLKRFLTTLQQFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQNPAQYLAQHEQLLLDASTTSPVDSSELLLDVNENGKRRTPDRTKENGFDREPLHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPPQHYRLDDMAIAHHYRDSYRHPSHRDLRDRNRPMGLHGTRQEEMIDHRLTDREWAEEWKHLDHLLNCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEDLKKGGGSSSSHSRQQSPVNPDPVALDAHREFLHRPASGYVPEEIWKKAEEAVNEVKRQAMTELQKAVSEAERKAHDMITTERAKMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASETCSGCNTARYCGSFCQHKDWEKHHHICGQTLQAQQQGDTPAVSSSVTPNSGAGSPMDTPPAATPRSTTPGTPSTIETTPR |
| Relations | 12 |
| Pathways | Acute Myeloid Leukemia, AML1-ETO in AML, Onco-fusion proteins in AML |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AML1-ETO | down-regulates quantity by repression 
transcriptional regulation
|
hsa-mir-223 | 0.4 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | Acute Myeloid Leukemia | |||
| + | AML1-ETO | down-regulates activity
binding
|
SPI1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML | |||
| + | AML1-ETO | down-regulates quantity by repression 
transcriptional regulation
|
PTPRC | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML | |||
| + | AML1-ETO | up-regulates activity 
binding
|
AP1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, Onco-fusion proteins in AML | |||
| + | AML1-ETO | up-regulates quantity by expression 
transcriptional regulation
|
PTGS2 | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML | |||
| + | AML1-ETO | down-regulates activity
binding
|
CEBPA | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, Onco-fusion proteins in AML | |||
| + | AML1-ETO | down-regulates quantity by repression
transcriptional regulation
|
JAK2 | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, Onco-fusion proteins in AML | |||
| + | AML1-ETO | down-regulates
transcriptional regulation
|
CDKN2A | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, Onco-fusion proteins in AML | |||
| + | AML1-ETO | down-regulates activity
binding
|
Core Binding Factor complex | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | AML1-ETO in AML | |||
| + | AML1-ETO | up-regulates quantity by expression
transcriptional regulation
|
KIT | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, Onco-fusion proteins in AML | |||
| + | AML1-ETO | down-regulates activity
binding
|
JUN | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML | |||