| + |
MAPK14 | up-regulates 
phosphorylation
|
PPARGC1A |
0.583 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112766 |
Ser266 |
SLPLTPEsPNDPKGS |
Homo sapiens |
|
| pmid |
sentence |
| 11741533 |
Cytokine stimulation of energy expenditure through p38 map kinase activation of ppargamma coactivator-1we show here that many cytokines activate the transcriptional ppar gamma coactivator-1 (pgc-1) through phosphorylation by p38 kinase, resulting in stabilization and activation of pgc-1 proteinp38 mapk directly phosphorylates pgc-1 on residues threonine 262, serine 265, and threonine 298 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112770 |
Thr263 |
TTLSLPLtPESPNDP |
Homo sapiens |
|
| pmid |
sentence |
| 11741533 |
Cytokine stimulation of energy expenditure through p38 map kinase activation of ppargamma coactivator-1we show here that many cytokines activate the transcriptional ppar gamma coactivator-1 (pgc-1) through phosphorylation by p38 kinase, resulting in stabilization and activation of pgc-1 proteinp38 mapk directly phosphorylates pgc-1 on residues threonine 262, serine 265, and threonine 298 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-112774 |
Thr299 |
AGLTPPTtPPHKANQ |
Homo sapiens |
|
| pmid |
sentence |
| 11741533 |
Cytokine stimulation of energy expenditure through p38 map kinase activation of ppargamma coactivator-1we show here that many cytokines activate the transcriptional ppar gamma coactivator-1 (pgc-1) through phosphorylation by p38 kinase, resulting in stabilization and activation of pgc-1 proteinp38 mapk directly phosphorylates pgc-1 on residues threonine 262, serine 265, and threonine 298 |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| + |
AMPK | up-regulates activity
phosphorylation
|
PPARGC1A |
0.5 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-228646 |
Ser539 |
SLFNVSPsCSSFNSP |
Mus musculus |
|
| pmid |
sentence |
| 17609368 |
AMPK phosphorylates PGC-1alpha directly both in vitro and in cells. These direct phosphorylations of the PGC-1alpha protein at threonine-177 and serine-538 are required for the PGC-1alpha-dependent induction of the PGC-1alpha promoter |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209940 |
Ser539 |
SLFNVSPsCSSFNSP |
Homo sapiens |
|
| pmid |
sentence |
| 20640476 |
AMPK can directly phosphorylate PGC-1a at Thr177 and Ser538 in in vitro assays PGC-1a phosphorylation might not directly affect its intrinsic coactivation activity, but, rather, release it from its repressor protein p160myb [79] and/or allow deacetylation and subsequent activation by SIRT1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-228642 |
Thr178 |
NHNHRIRtNPAIVKT |
Mus musculus |
|
| pmid |
sentence |
| 17609368 |
AMPK phosphorylates PGC-1alpha directly both in vitro and in cells. These direct phosphorylations of the PGC-1alpha protein at threonine-177 and serine-538 are required for the PGC-1alpha-dependent induction of the PGC-1alpha promoter |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209936 |
Thr178 |
NHNHRIRtNPAIVKT |
Homo sapiens |
|
| pmid |
sentence |
| 20640476 |
AMPK can directly phosphorylate PGC-1a at Thr177 and Ser538 in in vitro assays PGC-1a phosphorylation might not directly affect its intrinsic coactivation activity, but, rather, release it from its repressor protein p160myb [79] and/or allow deacetylation and subsequent activation by SIRT1 |
|
| Publications: |
4 |
Organism: |
Mus Musculus, Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | AMPK Signaling, Circadian clock, MTOR Signaling |
| + |
PRKAA1 | up-regulates activity
phosphorylation
|
PPARGC1A |
0.572 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-228654 |
Ser539 |
SLFNVSPsCSSFNSP |
Mus musculus |
|
| pmid |
sentence |
| 17609368 |
AMPK phosphorylates PGC-1alpha directly both in vitro and in cells. These direct phosphorylations of the PGC-1alpha protein at threonine-177 and serine-538 are required for the PGC-1alpha-dependent induction of the PGC-1alpha promoter |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156780 |
Thr178 |
NHNHRIRtNPAIVKT |
Homo sapiens |
|
| pmid |
sentence |
| 17609368 |
Ampk phosphorylates pgc-1alpha directly both in vitro and in cells. These direct phosphorylations of the pgc-1alpha protein at threonine-177 and serine-538. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| Tissue: |
Skeletal Muscle, Muscle, Skeletal Muscle |
| + |
AMPK | up-regulates
phosphorylation
|
PPARGC1A |
0.5 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216647 |
Ser539 |
SLFNVSPsCSSFNSP |
Homo sapiens |
|
| pmid |
sentence |
| 17609368 |
Ampk phosphorylates pgc-1alpha directly both in vitro and in cells. These direct phosphorylations of the pgc-1alpha protein at threonine-177 and serine-538. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216651 |
Thr178 |
NHNHRIRtNPAIVKT |
Homo sapiens |
|
| pmid |
sentence |
| 17609368 |
Ampk phosphorylates pgc-1alpha directly both in vitro and in cells. These direct phosphorylations of the pgc-1alpha protein at threonine-177 and serine-538. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| Pathways: | AMPK Signaling, Circadian clock, MTOR Signaling |
| + |
AKT1 | down-regulates activity 
phosphorylation
|
PPARGC1A |
0.448 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252502 |
Ser571 |
RMRSRSRsFSRHRSC |
Homo sapiens |
|
| pmid |
sentence |
| 17554339 |
Here we describe a mechanism by which insulin, through the intermediary protein kinase akt2/protein kinase b (pkb)-beta, elicits the phosphorylation and inhibition of the transcriptional coactivator peroxisome proliferator-activated receptor-coactivator 1alpha (pgc-1alpha), a global regulator of hepatic metabolism during fasting / phosphorylation of pgc-1alpha At ser570 Is required for akt to inhibit recruitment of pgc-1alpha To chromatin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Liver |
| + |
AKT | down-regulates activity
phosphorylation
|
PPARGC1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-155532 |
Ser571 |
RMRSRSRsFSRHRSC |
Homo sapiens |
|
| pmid |
sentence |
| 17554339 |
Here we describe a mechanism by which insulin, through the intermediary protein kinase akt2/protein kinase b (pkb)-beta, elicits the phosphorylation and inhibition of the transcriptional coactivator peroxisome proliferator-activated receptor-coactivator 1alpha (pgc-1alpha), a global regulator of hepatic metabolism during fasting / phosphorylation of pgc-1alpha At ser570 Is required for akt to inhibit recruitment of pgc-1alpha To chromatin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Liver |
| Pathways: | AMPK Signaling, MTOR Signaling |
| + |
AKT2 | down-regulates
phosphorylation
|
PPARGC1A |
0.349 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-155536 |
Ser571 |
RMRSRSRsFSRHRSC |
Homo sapiens |
|
| pmid |
sentence |
| 17554339 |
Here we describe a mechanism by which insulin, through the intermediary protein kinase akt2/protein kinase b (pkb)-beta, elicits the phosphorylation and inhibition of the transcriptional coactivator peroxisome proliferator-activated receptor-coactivator 1alpha (pgc-1alpha), a global regulator of hepatic metabolism during fasting / phosphorylation of pgc-1? At ser?570 Is required for akt to inhibit recruitment of pgc-1? To chromatin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT2 | down-regulates activity
phosphorylation
|
PPARGC1A |
0.349 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262626 |
Ser571 |
RMRSRSRsFSRHRSC |
Mus musculus |
|
| pmid |
sentence |
| 17554339 |
Here we describe a mechanism by which insulin, through the intermediary protein kinase Akt2/protein kinase B (PKB)-beta, elicits the phosphorylation and inhibition of the transcriptional coactivator peroxisome proliferator-activated receptor-coactivator 1alpha (PGC-1alpha), a global regulator of hepatic metabolism during fasting. Akt phosphorylates PGC-1α at Ser 570. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PRKDC | down-regulates quantity by destabilization
phosphorylation
|
PPARGC1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277911 |
Ser636 |
SRRPRYDsYEEYQHE |
Homo sapiens |
Glioblastoma Multiforme Cell Line |
| pmid |
sentence |
| 36696363 |
Mechanistically, PGC1α was phosphorylated at serine (S) 636 by DNA-dependent protein kinase in response to irradiation. Phosphorylation at S636 promoted the degradation of PGC1α by facilitating its binding to the E3 ligase RNF34. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARGC1A | down-regulates quantity by repression 
transcriptional regulation
|
NfKb-p65/p50 |
0.365 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217978 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20404331 |
In mouse muscles, overexpression of PGC-1beta (like PGC-1alpha) inhibited denervation atrophy, ubiquitin ligase induction, and transcription by NFkappaB |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Skeletal Muscle |
| + |
PPARGC1A | down-regulates
|
FOXO3 |
0.393 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-186058 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19491292 |
Nuclear pgc-1alpha and foxo3a respond in a reciprocal manner following aicar treatment. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling |
| + |
PPARGC1A | up-regulates 
|
Gluconeogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209932 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20640476 |
However, in contrast to the role of AMPK, most reports to date indicate that PGC-1a induces gluconeogenesis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling, Circadian clock |
| + |
PPARGC1A | down-regulates quantity by repression
transcriptional regulation
|
MSTN |
0.361 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256151 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23217713 |
PGC-1 alpha specifically induces IGF1 and represses myostatin, and expression of PGC-1a 4 in vitro and in vivo induces robust skeletal muscle hypertrophy |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PPARGC1A | up-regulates quantity by expression
transcriptional regulation
|
OTC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255056 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 16891307 |
Overexpression of SRC1 and PGC1alpha by recombinant adenoviruses led to a significant up-regulation of well characterized HNF4alpha-dependent genes (ApoCIII, ApoAV, PEPCK, AldoB, OTC, and CYP7A1) and forced HepG2 cells toward a more differentiated phenotype as demonstrated by increased ureogenic rate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FOXO | down-regulates
|
PPARGC1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252915 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
Foxo1 antagonized ppargamma activity and vice versa indicating that these transcription factors functionally interact in a reciprocal antagonistic manner. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252916 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20577053 |
Foxo1 antagonized ppargamma activity and vice versa indicating that these transcription factors functionally interact in a reciprocal antagonistic manner. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PPARGC1A | up-regulates quantity by expression
transcriptional regulation
|
ARNTL |
0.515 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268031 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17476214 |
Transcriptional coactivator PGC-1α integrates the mammalian clock and energy metabolism. Here we show that PGC-1alpha (Ppargc1a), a transcriptional coactivator that regulates energy metabolism, is rhythmically expressed in the liver and skeletal muscle of mice. PGC-1alpha stimulates the expression of clock genes, notably Bmal1 (Arntl) and Rev-erbalpha (Nr1d1), through coactivation of the ROR family of orphan nuclear receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock |
| + |
PPARGC1A | up-regulates quantity by expression
transcriptional regulation
|
CAV3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254261 |
|
|
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 15199055 |
Furthermore, we show that the muscle carnitine palmitoyltransferase-1 and caveolin-3 promoters are directly regulated by ROR and coactivated by p300 and PGC-1. This study implicates RORs in the control of lipid homeostasis in skeletal muscle. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
PPARGC1A | up-regulates quantity by expression
transcriptional regulation
|
CYP7A1 |
0.435 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255057 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 16891307 |
Overexpression of SRC1 and PGC1alpha by recombinant adenoviruses led to a significant up-regulation of well characterized HNF4alpha-dependent genes (ApoCIII, ApoAV, PEPCK, AldoB, OTC, and CYP7A1) and forced HepG2 cells toward a more differentiated phenotype as demonstrated by increased ureogenic rate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARGC1A | up-regulates quantity by expression
transcriptional regulation
|
CYCS |
0.381 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253097 |
|
|
Mus musculus |
Adipocyte |
| pmid |
sentence |
| 23021218 |
PGC1a is known to drive the expression of many genes involved in mitochondrial oxidative phosphorylation, including cytochrome c (CytC) and the cyto- chrome C oxidative (COX) subunits (CoxIII, Cox4il, Cox5b, Cox7a, and Cox8b). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FOXO1 | down-regulates
|
PPARGC1A |
0.577 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-142150 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
Foxo1 antagonized ppargamma activity and vice versa indicating that these transcription factors functionally interact in a reciprocal antagonistic manner. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166352 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20577053 |
Foxo1 antagonized ppargamma activity and vice versa indicating that these transcription factors functionally interact in a reciprocal antagonistic manner. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
RNF34 | down-regulates quantity by destabilization
ubiquitination
|
PPARGC1A |
0.321 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253393 |
|
|
|
|
| pmid |
sentence |
| 26971449 |
We then examined the effect of necdin on ubiquitin-dependent degradation of PGC-1α using Rnf34, a PGC-1α E3 ubiquitin ligase22. Rnf34 reduced the PGC-1α level, and necdin completely inhibited the reduction (Fig. 4i). In addition, necdin strongly suppressed Rnf34-mediated ubiquitination of PGC-1α (Fig. 4j). Necdin also protected PGC-1α against ubiquitination mediated by Fbxw7, another PGC-1α E3 ubiquitin ligase23 (Fig. 4k). These data indicate that necdin stabilizes PGC-1α by inhibiting its degradation in the ubiquitin-proteasomal system. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277912 |
|
|
Homo sapiens |
Glioblastoma Multiforme Cell Line |
| pmid |
sentence |
| 36696363 |
Mechanistically, PGC1α was phosphorylated at serine (S) 636 by DNA-dependent protein kinase in response to irradiation. Phosphorylation at S636 promoted the degradation of PGC1α by facilitating its binding to the E3 ligase RNF34. |
|
| Publications: |
2 |
Organism: |
, Homo Sapiens |
| + |
PPARGC1A | down-regulates quantity by repression
transcriptional regulation
|
NFKB1 |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217969 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20404331 |
In mouse muscles, overexpression of PGC-1beta (like PGC-1alpha) inhibited denervation atrophy, ubiquitin ligase induction, and transcription by NFkappaB |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Skeletal Muscle |
| + |
SIRT1 | up-regulates activity
deacetylation
|
PPARGC1A |
0.797 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209962 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20640476 |
AMPK can directly phosphorylate PGC-1a at Thr177 and Ser538 in in vitro assays PGC-1a phosphorylation might not directly affect its intrinsic coactivation activity, but, rather, release it from its repressor protein p160myb [79] and/or allow deacetylation and subsequent activation by SIRT1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217963 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24003218 |
SIRT1 overexpression reduces muscle wasting by blocking the activation of FoxO1 and 3 SIRT1 activation has been reported to increase dramatically endurance exercise through the activation of PGC-1_ in muscle, which stimulates fatty acid oxidation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| Tissue: |
Skeletal Muscle |
| Pathways: | AMPK Signaling, Circadian clock |
| + |
SIRT1 | up-regulates quantity
transcriptional regulation
|
PPARGC1A |
0.797 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238790 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19553684 |
Collectively, these data indicate that SIRT1 controls PGC-1alpha gene expression in skeletal muscle and that MyoD is a key mediator of this action |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling, Circadian clock |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
PPARGC1A |
0.55 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256150 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11557984 |
CREB was found to induce expression of the gluconeogenic programme through the nuclear receptor coactivator PGC-1, which is shown here to be a direct target for CREB regulation in vivo |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | AMPK Signaling |
| + |
BMP7 | up-regulates quantity by expression
transcriptional regulation
|
PPARGC1A |
0.289 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180314 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18719589 |
Bmp7 activates a full program of brown adipogenesis including induction of early regulators of brown fat fate prdm16 (pr-domain-containing 16;ref. 4) and pgc-1alpha (peroxisome proliferator-activated receptor-gamma (ppargamma) coactivator-1alpha;ref. 5), increased expression of the brown-fat-defining marker uncoupling protein 1 (ucp1) and adipogenic transcription factors ppargamma and ccaat/enhancer-binding proteins (c/ebps), and induction of mitochondrial biogenesis via p38 mitogen-activated protein (map) kinase-(also known as mapk14) and pgc-1-dependent pathways |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRPV4 | down-regulates quantity by repression
transcriptional regulation
|
PPARGC1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253095 |
|
|
Mus musculus |
Adipocyte |
| pmid |
sentence |
| 23021218 |
TRPV4 negatively regulated the expression of PGC1α, UCP1, and cellular respiration. Additionally, it potently controlled the expression of multiple proinflammatory genes involved in the development of insulin resistance. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
STOML2 | up-regulates quantity by expression
transcriptional regulation
|
PPARGC1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260379 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21746876 |
We performed real-time RT-PCR to measure the levels of PGC-1alpha mRNA and found that these were increased in SLP-2hi cells (Fig. 3h), supporting the idea that upregulation of SLP-2 expression is associated with an increase in the expression of mitochondrially targeted genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GSK3B | down-regulates quantity
phosphorylation
|
PPARGC1A |
0.478 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279723 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25118933 |
GSK3\u03b2 is an important serine/threonine kinase to regulate PPAR\u03b3 coactivator-1\u03b1 degradation. , GSK3\u03b2 reduces PPAR\u03b3 coactivator-1\u03b1 levels by phosphorylating PPAR\u03b3 coactivator-1\u03b1 and subsequently stimulating PPAR\u03b3 coactivator-1\u03b1 degradation by the ubiquitin-proteasomal system.|Within them, GSK3beta, which can phosphorylate PGC-1alpha and promote its ubiquitin mediated degradation , , was upregulated significantly in mnd2 mouse brain and spinal cord compared with that in wide-type mice (XREF_FIG). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | MTOR Signaling |
| + |
PPARGC1A | up-regulates quantity by expression
transcriptional regulation
|
ALDOB |
0.244 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255055 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 16891307 |
Overexpression of SRC1 and PGC1alpha by recombinant adenoviruses led to a significant up-regulation of well characterized HNF4alpha-dependent genes (ApoCIII, ApoAV, PEPCK, AldoB, OTC, and CYP7A1) and forced HepG2 cells toward a more differentiated phenotype as demonstrated by increased ureogenic rate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARGC1A | up-regulates quantity by expression
transcriptional regulation
|
IGF1 |
0.339 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256152 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23217713 |
PGC-1 alpha specifically induces IGF1 and represses myostatin, and expression of PGC-1a 4 in vitro and in vivo induces robust skeletal muscle hypertrophy |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PPARGC1A | up-regulates
|
GPX1 |
0.315 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253396 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18074631 |
In fact, experiments with either genetic knockouts or RNAi for the PGC1s show that the ability of ROS to induce a ROS scavenging programme depends entirely on the PGC1s. This includes genes encoding mitochondrial proteins like SOD2, but also includes cytoplasmic proteins such as catalase and GPX1. Cells lacking PGC1alpha are hypersensitive to death from oxidative stress caused by H2O2 or paraquat. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PPARGC1A | up-regulates quantity by expression
transcriptional regulation
|
Aldolase |
0.255 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270226 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 16891307 |
Overexpression of SRC1 and PGC1alpha by recombinant adenoviruses led to a significant up-regulation of well characterized HNF4alpha-dependent genes (ApoCIII, ApoAV, PEPCK, AldoB, OTC, and CYP7A1) and forced HepG2 cells toward a more differentiated phenotype as demonstrated by increased ureogenic rate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXW7 | down-regulates quantity by destabilization
ubiquitination
|
PPARGC1A |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253394 |
|
|
|
|
| pmid |
sentence |
| 26971449 |
We then examined the effect of necdin on ubiquitin-dependent degradation of PGC-1α using Rnf34, a PGC-1α E3 ubiquitin ligase22. Rnf34 reduced the PGC-1α level, and necdin completely inhibited the reduction (Fig. 4i). In addition, necdin strongly suppressed Rnf34-mediated ubiquitination of PGC-1α (Fig. 4j). Necdin also protected PGC-1α against ubiquitination mediated by Fbxw7, another PGC-1α E3 ubiquitin ligase23 (Fig. 4k). These data indicate that necdin stabilizes PGC-1α by inhibiting its degradation in the ubiquitin-proteasomal system. |
|
| Publications: |
1 |
| + |
TFEB | up-regulates quantity by expression
transcriptional regulation
|
PPARGC1A |
0.38 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276708 |
|
|
|
|
| pmid |
sentence |
| 33176151 |
Here we show that the transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy, is induced by starvation through an autoregulatory feedback loop and exerts a global transcriptional control on lipid catabolism via Ppargc1α and Ppar1α. |
|
| Publications: |
1 |
| Pathways: | MTOR Signaling |
| + |
NDN | up-regulates quantity by stabilization
binding
|
PPARGC1A |
0.328 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253390 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26971449 |
Necdin binds and stabilizes PGC-1α|Necdin strongly stabilizes PGC-1α by inhibiting its ubiquitin-dependent degradation. Forced expression of necdin enhances mitochondrial function in primary cortical neurons and human SH-SY5Y neuroblastoma cells to prevent mitochondrial respiratory chain inhibitor-induced degeneration. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARGC1A | down-regulates quantity by repression
transcriptional regulation
|
FOXO3 |
0.393 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217966 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20404331 |
Capacity of PGC-1alpha and PGC-1beta to inhibit FoxO3 and NFkappaB actions and proteolysis helps explain how exercise prevents muscle atrophy.overexpression of PGC-1_ inhibits muscle wasting induced by denervation, starvation, and even caFoxO3 expression |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | AMPK Signaling |
| + |
CLK2 | down-regulates activity
phosphorylation
|
PPARGC1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278228 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20074525 |
Clk2 could also repress PGC-1alpha activation of Foxo1 on the IRS response element , as well as repress the Pepck promoter .|Clk2 phosphorylates and represses PGC-1\u03b1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARGC1A | up-regulates quantity by expression
transcriptional regulation
|
COX4I1 |
0.398 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253098 |
|
|
Mus musculus |
Adipocyte |
| pmid |
sentence |
| 23021218 |
PGC1a is known to drive the expression of many genes involved in mitochondrial oxidative phosphorylation, including cytochrome c (CytC) and the cyto- chrome C oxidative (COX) subunits (CoxIII, Cox4il, Cox5b, Cox7a, and Cox8b). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PPARGC1A | up-regulates quantity by expression
transcriptional regulation
|
SLC2A4 |
0.622 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156769 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17609368 |
Pgc-1alpha protein is required for ampk action on glut4 gene expression and mitochondrial function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
PPARGC1A | up-regulates quantity by expression
transcriptional regulation
|
PPARGC1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156783 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17609368 |
Furthermore, ampk directly phosphorylates pgc-1?, And this phosphorylation mediates an increase in pgc-1? Protein action on the pgc-1? Promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| Pathways: | AMPK Signaling, Circadian clock, MTOR Signaling |
| + |
STAT6 | up-regulates quantity by expression
transcriptional regulation
|
PPARGC1A |
0.256 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249538 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20508200 |
Phosphorylated STAT6 dimerizes and translocates to the nucleus where it induces the expression of its target genes, including markers (Arg1, Chi3l3, Mrc1, Mgl1, and Retnla) and regulators (Pparalpha, Ppargamma and PGC-1?) of alternative activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARGC1A | up-regulates activity
|
ESRRA |
0.923 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253392 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18074631 |
The PGC1 transcriptional coactivators are major regulators of several crucial aspects of energy metabolism. PGC1alpha controls many aspects of oxidative metabolism, including mitochondrial biogenesis and respiration through the coactivation of many nuclear receptors, and factors outside the nuclear receptor family. ERRalpha, NRF1 and NRF2 are key targets of the PGC1s in mitochondrial biogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ZNF746 | up-regulates quantity by expression
transcriptional regulation
|
PPARGC1A |
0.446 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277627 |
|
|
Homo sapiens |
SH-SY5Y Cell |
| pmid |
sentence |
| 21376232 |
PARIS represses the expression of the transcriptional coactivator, PGC-1α and the PGC-1α target gene, NRF-1 by binding to insulin response sequences in the PGC-1α promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARGC1A | up-regulates quantity by expression
transcriptional regulation
|
APOC3 |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255059 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 16891307 |
Overexpression of SRC1 and PGC1alpha by recombinant adenoviruses led to a significant up-regulation of well characterized HNF4alpha-dependent genes (ApoCIII, ApoAV, PEPCK, AldoB, OTC, and CYP7A1) and forced HepG2 cells toward a more differentiated phenotype as demonstrated by increased ureogenic rate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARGC1A | up-regulates
|
SOD2 |
0.373 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253395 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18074631 |
In fact, experiments with either genetic knockouts or RNAi for the PGC1s show that the ability of ROS to induce a ROS scavenging programme depends entirely on the PGC1s. This includes genes encoding mitochondrial proteins like SOD2, but also includes cytoplasmic proteins such as catalase and GPX1. Cells lacking PGC1alpha are hypersensitive to death from oxidative stress caused by H2O2 or paraquat. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PPARGC1A | up-regulates
|
Mitochondrial_biogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-228618 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23277535 |
PGC1a is a positive regulator of mitochondrial biogenesis and respiration, adaptive thermogenesis, gluconeogenesis as well as many other metabolic proc |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | MTOR Signaling |
| + |
PPARGC1A | up-regulates quantity by expression
transcriptional regulation
|
COX5B |
0.326 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253099 |
|
|
Mus musculus |
Adipocyte |
| pmid |
sentence |
| 23021218 |
PGC1a is known to drive the expression of many genes involved in mitochondrial oxidative phosphorylation, including cytochrome c (CytC) and the cyto- chrome C oxidative (COX) subunits (CoxIII, Cox4il, Cox5b, Cox7a, and Cox8b). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PPARG | up-regulates quantity by expression
transcriptional regulation
|
PPARGC1A |
0.903 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263984 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 32991581 |
NFIA binds to and activates the brown-fat-specific enhancers even before differentiation and later facilitates the binding of PPARgamma|NFIA has at least three functions on the transcriptional regulation of brown fat [2]. First, NFIA activates adipogenesis per se, through activating the transcription of Pparg, which encodes PPARgamma. Second, NFIA also activates the brown-fat-specific gene expression (such as Ucp1 and Ppargc1a) independent of the degree of adipocyte differentiation, through facilitating the binding of PPARgamma to the brown-fat-specific enhancers. Third, NFIA represses myogenesis through suppression of myogenic transcription factors such as Myod1 as well as Myog, |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Circadian clock, MTOR Signaling |
| + |
PPARGC1A | up-regulates quantity by expression
transcriptional regulation
|
APOA5 |
0.281 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255058 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 16891307 |
Overexpression of SRC1 and PGC1alpha by recombinant adenoviruses led to a significant up-regulation of well characterized HNF4alpha-dependent genes (ApoCIII, ApoAV, PEPCK, AldoB, OTC, and CYP7A1) and forced HepG2 cells toward a more differentiated phenotype as demonstrated by increased ureogenic rate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARGC1A | up-regulates quantity by expression
transcriptional regulation
|
PCK2 |
0.395 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255060 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 16891307 |
Overexpression of SRC1 and PGC1alpha by recombinant adenoviruses led to a significant up-regulation of well characterized HNF4alpha-dependent genes (ApoCIII, ApoAV, PEPCK, AldoB, OTC, and CYP7A1) and forced HepG2 cells toward a more differentiated phenotype as demonstrated by increased ureogenic rate. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIRT1 | up-regulates quantity by expression
transcriptional regulation
|
PPARGC1A |
0.797 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268033 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21633182 |
Interestingly, SIRT1 suppresses PPARγ but activates PGC-1α , and thus affects the clock network through multiple mechanisms. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AMPK Signaling, Circadian clock |
| + |
PPARGC1A | down-regulates
|
FOXO |
0.577 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252970 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19491292 |
Nuclear pgc-1alpha and foxo3a respond in a reciprocal manner following aicar treatment. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ROS | up-regulates
|
PPARGC1A |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253397 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18074631 |
In fact, experiments with either genetic knockouts or RNAi for the PGC1s show that the ability of ROS to induce a ROS scavenging programme depends entirely on the PGC1s. This includes genes encoding mitochondrial proteins like SOD2, but also includes cytoplasmic proteins such as catalase and GPX1. Cells lacking PGC1alpha are hypersensitive to death from oxidative stress caused by H2O2 or paraquat. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
BMP7 | up-regulates
transcriptional regulation
|
PPARGC1A |
0.289 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210056 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18719589 |
Bmp7 activates a full program of brown adipogenesis including induction of early regulators of brown fat fate prdm16 (pr-domain-containing 16; ref. 4) and pgc-1alpha (peroxisome proliferator-activated receptor-gamma (ppargamma) coactivator-1alpha; ref. 5), increased expression of the brown-fat-defining marker uncoupling protein 1 (ucp1) and adipogenic transcription factors ppargamma and ccaat/enhancer-binding proteins (c/ebps), and induction of mitochondrial biogenesis via p38 mitogen-activated protein (map) kinase-(also known as mapk14) and pgc-1-dependent pathways |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARGC1A | up-regulates activity
|
NRF1 |
0.707 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253391 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26971449 |
PGC-1 family transcriptional coactivators enhance the activities of the nuclear respiratory factors NRF1 and NRF2, which induce transactivation of many genes encoding mitochondria-specific proteins involved in respiratory chain, mitochondrial DNA transcription/replication and protein import/assembly |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARGC1A | up-regulates quantity by expression
transcriptional regulation
|
SOD2 |
0.373 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251762 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20089851 |
PGC-1α has been reported to induce Mn-SOD expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARGC1A | down-regulates quantity by repression
transcriptional regulation
|
FOXO |
0.577 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252969 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20404331 |
Capacity of PGC-1alpha and PGC-1beta to inhibit FoxO3 and NFkappaB actions and proteolysis helps explain how exercise prevents muscle atrophy.overexpression of PGC-1_ inhibits muscle wasting induced by denervation, starvation, and even caFoxO3 expression |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Skeletal Muscle |
| + |
PPARGC1A | up-regulates quantity by expression
transcriptional regulation
|
CPT1B |
0.403 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254262 |
|
|
Chlorocebus aethiops |
COS-1 Cell |
| pmid |
sentence |
| 15199055 |
Furthermore, we show that the muscle carnitine palmitoyltransferase-1 and caveolin-3 promoters are directly regulated by ROR and coactivated by p300 and PGC-1. This study implicates RORs in the control of lipid homeostasis in skeletal muscle. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
PPARGC1A | up-regulates quantity by expression
transcriptional regulation
|
NR1D1 |
0.518 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268030 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 17476214 |
Transcriptional coactivator PGC-1α integrates the mammalian clock and energy metabolism. Here we show that PGC-1alpha (Ppargc1a), a transcriptional coactivator that regulates energy metabolism, is rhythmically expressed in the liver and skeletal muscle of mice. PGC-1alpha stimulates the expression of clock genes, notably Bmal1 (Arntl) and Rev-erbalpha (Nr1d1), through coactivation of the ROR family of orphan nuclear receptors. Chromatin immunoprecipitation (ChIP) assays in HepG2 cells indicate that PGC-1α is present near RORE on the proximal Bmal1 promoter.These results indicate that PGC-1α activates Bmal1 transcription by altering the local chromatin environment from a repressive to an active state. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Circadian clock |
4.0
PPARGC1A
- 
- 