Glucocorticoid receptor Signaling

Pathway ID: SIGNOR-GCRView in NDEx

Description: Glucocorticoids are steroid hormones involved in various metabolic and homeostatic functions. They are synthesized by the adrenal cortex and their physiological and pharmacological actions are mediated through binding with the glucocorticoid receptor (GR). The glucocorticoid receptor, also known as NR3C1, translocates in the nucleus and modulates, positively or negatively, the transcription of thousands of genes by direct binding to DNA response elements and/or by physically associating with other transcription factors.

Curated by: Federica Ferrentino

24 Seed Entities

Organism:
Name Primary ID
JUN P05412
prednisolone CHEBI:8378
HSP90AA1 P07900
NCOA1 Q15788
budesonide CHEBI:3207
STAT5A P42229
dexamethasone CHEBI:41879
prednisone CHEBI:8382
dehydroepiandrosterone CHEBI:28689
6alpha-methylprednisolone CHEBI:6888
NFKB1 P19838
NR3C1 P04150
MAPK1 P28482
HNF4A P41235
NR3C1/STAT5A SIGNOR-C84
NfKb-p65/p50 SIGNOR-C13
Proliferation SIGNOR-PH4
Inflammation SIGNOR-PH12
betamethasone CHEBI:3077
MAPK14 Q16539
cortisone CHEBI:16962
MAPK8 P45983
MAPK3 P27361
Adipogenesis SIGNOR-PH26