4.0
Glucocorticoid receptor Signaling
Pathway ID: SIGNOR-GCR
View in NDEx
Description: Glucocorticoids are steroid hormones involved in various metabolic and homeostatic functions. They are synthesized by the adrenal cortex and their physiological and pharmacological actions are mediated through binding with the glucocorticoid receptor (GR). The glucocorticoid receptor, also known as NR3C1, translocates in the nucleus and modulates, positively or negatively, the transcription of thousands of genes by direct binding to DNA response elements and/or by physically associating with other transcription factors.
Curated by: Federica Ferrentino
Use SIGNOR Cytoscape App
Description: Glucocorticoids are steroid hormones involved in various metabolic and homeostatic functions. They are synthesized by the adrenal cortex and their physiological and pharmacological actions are mediated through binding with the glucocorticoid receptor (GR). The glucocorticoid receptor, also known as NR3C1, translocates in the nucleus and modulates, positively or negatively, the transcription of thousands of genes by direct binding to DNA response elements and/or by physically associating with other transcription factors.
Curated by: Federica Ferrentino
Use SIGNOR Cytoscape App
24 Seed Entities
Organism: 
|
Name | Primary ID |
|---|---|
| JUN | P05412 |
| prednisolone | CHEBI:8378 |
| HSP90AA1 | P07900 |
| NCOA1 | Q15788 |
| budesonide | CHEBI:3207 |
| STAT5A | P42229 |
| dexamethasone | CHEBI:41879 |
| prednisone | CHEBI:8382 |
| dehydroepiandrosterone | CHEBI:28689 |
| 6alpha-methylprednisolone | CHEBI:6888 |
| NFKB1 | P19838 |
| NR3C1 | P04150 |
| MAPK1 | P28482 |
| HNF4A | P41235 |
| NR3C1/STAT5A | SIGNOR-C84 |
| NfKb-p65/p50 | SIGNOR-C13 |
| Proliferation | SIGNOR-PH4 |
| Inflammation | SIGNOR-PH12 |
| betamethasone | CHEBI:3077 |
| MAPK14 | Q16539 |
| cortisone | CHEBI:16962 |
| MAPK8 | P45983 |
| MAPK3 | P27361 |
| Adipogenesis | SIGNOR-PH26 |